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Stock availabilitIn Stock
In Stock
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CAS number
129-56-6
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Description
Jnk inhibitor
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Molecular weight
220,2 g/mol
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Primary research fields
Cell Signaling, Cancer, Apoptosis
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Other name
Anthra(1,9-cd)pyrazol-6(2H)-one, 1,9-Pyrazoloanthrone
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C14H8N2O
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Origin
Synthetic
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Purity pourcentage
>98%
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Soluble in
Soluble in DMSO or methanol
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Physical appearance
Yellow to brown solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: D2B - Toxic Material Causing Other Toxic Effects, Moderate skin irritant, Moderate respiratory irritant, Moderate eye irritant Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H315 - Causes skin irritation. H319 - Causes serious eye irritation. H335 - May cause respiratory irritation Precautionary Phrases: P261 - Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 - Wash skin thoroughly after handling. P271 - Use only outdoors or in a well-ventilated area. P280 - Wear protective gloves/ eye protection/ face protection. P302 + P352 - IF ON SKIN: Wash with plenty of soap and water. P304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312 – Call a POISON CENTER or doctor/ physician if you feel unwell. P321 - Specific treatment (see supplemental first aid instructions on this label). P332 + P313 - If skin irritation occurs: Get medical advice/ attention. P337 + P313 - If eye irritation persists: Get medical advice/ attention. P362 - Take off contaminated clothing and wash before reuse. P403 + P233 - Store in a well - ventilated place. Keep container tightly closed. P405 - Store locked up. P501 - Dispose of contents/ container to an approved waste disposal plant.
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PubChem number
8515
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Scientific context
Selective inhibitor of c-Jun N-terminal kinase (JNK). Competitively and reversibly inhibits JNK1, 2 and 3 (IC50 = 40 - 90 nM) with negligible activity at ERK2, p38β and a range of enzymes (IC50 > 10 µM). Active in vivo. Shown to have reduced selectivity over other protein kinases under certain conditions. Protects renal tubular epithelial cells against ischemia/reperfusion-induced apoptosis.
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Bibliography
1. Bennett B.L., et al. (2001) Proc. Natl. Acad. Sci. U.S.A. 98(24): 13681-6. 2. Schnabl B., et al. (2001) Hepatology. 34(5): 953-63. 3. Bain J., et al. (2003) Biochem. J. 371(Pt 1): 199-204. 4. Wang Y., et al. (2007) Life Sci. 80(22): 2067-75.
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Release date
17-Jul-2013
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of SP600125 (SIH-381), a Jnk inhibitor. CAS #: 129-56-6. Molecular Formula: C14H8N2O. Molecular Weight: 220.2 g/mol. Chemical structure of SP600125, a Jnk inhibitor (SIH-381). CAS # 129-56-6. Molecular Formula: C14H8N2O.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.01
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
