-
Stock availability
In Stock
-
Scientific context
Biliverdin Reductase (BVR) is a cytoplasmic enzyme that catalyzes the conversion of biliverdin to bilirubin by converting a double bond between the second and third pyrrole ring into a single bond (1). It is ubiqutiously expressed in all tissues- it occurs in cells and brain regiuons that already display HO-1 and HO-2, but also in regions and cell types with potential to induce stress proteins. It is unique among all enzymes in having two pH optima, using a different cofactor at each pH range, NADH at pH7.0 and NADPH at pH8.7 (2). It is not inactivated by heat shock, and have shown to abate inflammation, oxidative stress and apoptosis (3).
-
Protein target
BVR
-
Protein reactivity
Rat
-
Certificate of analysis
This product has been certified >90% pure using SDSPAGE analysis.
-
Protein description
Rat Natural BVR Full Length Protein
-
Other name
Biliverdin Reductase Protein, Biliverdin IX alpha reductase Protein, Biliverdin reductase A Protein, Biliverdin-IX alpha-reductase Protein, BLVR A Protein, BLVR Protein, Blvra Protein, BVR A Protein, BVRA Protein, Zinc metalloProtein, zinc-metalloprotein Protein
-
Primary research area
Cancer, Oxidative Stress
-
Category
Protein
-
Brand name
none
-
Origin
Natural
-
NCBI number
NP_446302.1
-
Gene number
116599
-
Protein number
P46844
-
Verified applications
WB, SDS-PAGE
-
Relevant bio activity
BVR Protein
-
Protein expression model
Native
-
Protein charasterics
Full Length
-
Peptide sequence
MDAEPKRKFGVVVVGVGRAGSVRLRDLKDPRSAAFLNLIGFVSRRELGSLDEVRQISLEDALRSQEIDVAYICSESSSHEDYIRQFLQAGKHVLVEYPMTLSFAAAQELWELAAQKGRVLHEEHVELLMEEFEFLRREVLGKELLKGSLRFTASPLEEERFGFPAFSGISRLTWLVSLFGELSLISATLEERKEDQYMKMTVQLETQNKGLLSWIEEKGPGLKRNRYVNFQFTSGSLEEVPSVGVNKNIFLKDQDIFVQKLLDQVSAEDLAAEKKRIMHCLGLASDIQKLCHQKK
-
Protein purification
Ion-exchange Purified
-
Purity pourcentage
>90% High purity
-
Recommended buffer for storage
10mM Tris pH7.5, 0.1mM EDTA, 0.2mM DTT, 20% glycerol
-
Protein concentration
Lot/batch specific. See included datasheet.
-
Protein specificity
~36 kDa
-
Protein tag
No tag
-
Storage recommendations
-80°C
-
Shipping recommendations
Blue Ice or 4°C
-
Supplementary useful information
Please see included datasheet or contact us
-
Protein cell localization
Cytoplasm
-
Bibliography
1. Singleton J.W., Laster L. (1965). J Biol Chem. 240: 4780-4789. 2. Kutty R.K., Maines M.D. (1981) J Biol Chem. 256: 3956-3962. 3. Mishra M., Ndisand J.F. (2014) Curr Pharm Des. 20(9): 1370-1391.
-
Release date
5-Jan-2015
-
PubMed number
Not added. Please refer to PubMed
-
Tested applications
to be tested
-
Tested species reactivity
to be tested
-
Representative figure
No Representative Data Available.
-
Representative figure legend
No Representative Data Available.
-
Warnings
Non-hazardous materials
-
Protein origin
Canada
-
Total weight kg
1.4
-
Net weight g
0.1
-
-
About
Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
-
Latin name
Rattus norvegicus
