Caspase 8, p18 (FLICE, MACH, Mch5) Antibody

• Catalog number
  GEN603159
• Price
  Please ask
• Size
  100ug

• Also known as
  Caspase 8, p18
• Other names
  Caspase-8; Caspase-8; caspase-8; FADD-like ICE; OTTHUMP00000163717; OTTHUMP00000163720; OTTHUMP00000165062; OTTHUMP00000165063; OTTHUMP00000165064; OTTHUMP00000206552; MACH-alpha-1/2/3 protein; apoptotic protease Mch-5; MACH-beta-1/2/3/4 protein; apoptotic cysteine protease; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; FADD-homologous ICE/CED-3-like protease; caspase 8, apoptosis-related cysteine protease; caspase 8, apoptosis-related cysteine peptidase; Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; FLICE; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog
• Category
  Antibodies
• Subcategory
  Mnoclonal antibodies
• Gene name
  CASP8; CASP8; CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8; FLJ17672; MGC78473; MCH5
• Gene name synonims
  CASP8; CASP8; CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8; FLJ17672; MGC78473; MCH5
• Other gene names
  CASP8; CASP8; CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8; FLJ17672; MGC78473; MCH5
• Clonality
  Monoclonal
• Immunoglobulin isotype
  IgG2b
• Clone
  6D220
• Host organism
  Mouse (Mus musculus)
• Source organism
  Human (Homo sapiens)
• Species reactivity
  Human (Homo sapiens); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
• Specificity and cross reactivity
  Recognizes human procaspase-8 and active human caspase-8. Detects procaspase-8 (p55/54), the intermediate cleavage products (p43/41) and the p18 active subunit of caspase-8 by Western blot. Does not recognize mouse caspase-8.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
• Purification method
  Affinity 97% (SDS-PAGE)Epitope-affinity purified.
• Form Appearance
  Supplied as a liquid in 0.15M PBS, pH 7.2, containing 1% BSA and 0.01% thimerosal.
• Concentration
  N/A
• Storage and shipping
  Store the antibody at -20 degrees Celsius.
• Tested applications
  Western Blot (WB), Immunoprecipitation (IP)
• Properties
  If you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Description
  Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
• French translation
  anticorps

• Gene target
  Caspase   p18   FLICE   MACH   Mch5  
• Gene symbol
  CASP8, CASP10, CFLAR
• Short name
  Caspase 8, p18 (FLICE, MACH, Mch5) Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  Anti-Caspase 8, p18 (FLICE, MACH, Mch5)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:1509
• Gene
  CASP8
• Long gene name
  caspase 8
• Synonyms gene name
  • caspase 8, apoptosis-related cysteine protease
  • caspase 8, apoptosis-related cysteine peptidase
• Synonyms
  • MCH5
  • MACH
  • FLICE
  • Casp-8
• GenBank acession
  • U60520
• Locus
  2q33.1
• Discovery year
  1996-11-11
• Entrez gene record
  841
• Pubmed identfication
  • 8681376
  • 8681377
• RefSeq identity
  • NM_001228
• Classification
  • Caspases
  • Death effector domain containing
  • Death inducing signaling complex
  • Ripoptosome
• VEGA ID
  OTTHUMG00000132821
• Locus Specific Databases
  • CASP8base: Mutation registry for Caspase 8 deficiency
  • LRG_34

Gene info

• Identity
  HGNC:1500
• Gene
  CASP10
• Long gene name
  caspase 10
• Synonyms gene name
  • caspase 10, apoptosis-related cysteine protease
  • caspase 10, apoptosis-related cysteine peptidase
• Synonyms
  • MCH4
  • FLICE-2
• Synonyms name
  • FAS-associated death domain protein interleukin-1B-converting enzyme 2
• GenBank acession
  • U60519
• Locus
  2q33.1
• Discovery year
  1997-04-21
• Entrez gene record
  843
• Pubmed identfication
  • 8755496
• RefSeq identity
  • NM_032977
• Classification
  • Caspases
  • Death effector domain containing
  • Death inducing signaling complex
• VEGA ID
  OTTHUMG00000132818
• Locus Specific Databases
  • CASP10base: Mutation registry for Autoimmune lymphoproliferative syndrome, type II (ALPS2)
  • LRG_33

Gene info

• Identity
  HGNC:1876
• Gene
  CFLAR
• Long gene name
  CASP8 and FADD like apoptosis regulator
• Synonyms gene
  • CASP8AP1
• Synonyms gene name
  • CASP8 and FADD-like apoptosis regulator
• Synonyms
  • CASH
  • Casper
  • CLARP
  • FLAME
  • FLIP
  • I-FLICE
  • MRIT
  • c-FLIP
  • cFLIP
• GenBank acession
  • AF005774
• Locus
  2q33.1
• Discovery year
  1999-05-07
• Entrez gene record
  8837
• Pubmed identfication
  • 9208847
  • 9217161
• RefSeq identity
  • NM_003879
• Classification
  • Receptor ligands
  • Death effector domain containing
  • Death inducing signaling complex
  • Ripoptosome
• VEGA ID
  OTTHUMG00000132819

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Similar products