EMAP-II Inhibitor Z-ASTD-FMK

• Catalog number
  1127-20C
• Price
  Please ask
• Size
  20 ul (10 mM)

• Alternative_name
  Z-ASTD-FMK, Z-ASTD-fluoromethylketone, EMAP-II Inhibitor(fluoromethylketone)
• Description
  A synthetic peptide that irreversibly inhibits EMAP II (Endothelial Monocyte-Activated Polypeptide II) activity released during apoptosis. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
• Structure Available
  No
• Peptide sequence
  Z-Ala-Ser-Thr-Asp(OMe)-FMK
• Salt Form
  No
• Molecular Formula
  C₂₄H₃₃FN₄O₁₀
• Molecular Weight
  556.54
• Cell Permeable
  Yes
• Purity
  >99% by HPLC
• Handling
  Protect from light and moisture
• Tag Line
  A EMAPII inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• MDL Number
  MFCD03453606
• PubChem CID
  44134690
• PubChem CID Link
• SMILES
  CC(C(C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CO)NC(=O)C(C)NC(=O)OCC1=CC=CC=C1)O
• InChi
  InChI=1S/C24H33FN4O10/c1-13(26-24(37)39-12-15-7-5-4-6-8-15)21(34)28-17(11-30)22(35)29-20(14(2)31)23(36)27-16(18(32)10-25)9-19(33)38-3/h4-8,13-14,16-17,20,30-31H,9-12H2,1-3H3,(H,26,37)(H,27,36)(H,28,34)(H,29,35)
• InChi Key
  LICIOVKJUZZCAM-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  EMAP-II   Inhibitor   Z-ASTD-FMK  
• Gene symbol
  AIMP1, PSMB7, PLA2G4F, HLA-Z, EML1, EML2, CRABP2, SPINK2, MGST2, EML5
• Short name
  EMAP-II Inhibitor Z-ASTD-FMK
• Alternative name
  EMAP-II suppressor Z-ASTD-FMK

Gene info

• Identity
  HGNC:10648
• Gene
  AIMP1
• Long gene name
  aminoacyl tRNA synthetase complex interacting multifunctional protein 1
• Synonyms gene
  • SCYE1
• Synonyms gene name
  • small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)
• Synonyms
  • EMAPII
  • EMAP-2
  • p43
• Synonyms name
  • EMAP II
  • ARS-interacting multifunctional protein 1
• GenBank acession
  • U10117
• Locus
  4q24
• Discovery year
  2000-04-13
• Entrez gene record
  9255
• Pubmed identfication
  • 7929199
  • 7545917
• RefSeq identity
  • NM_004757
• VEGA ID
  OTTHUMG00000131217

Gene info

• Identity
  HGNC:9544
• Gene
  PSMB7
• Long gene name
  proteasome 20S subunit beta 7
• Synonyms gene name
  • proteasome (prosome, macropain) subunit, beta type, 7
  • proteasome subunit beta 7
• Synonyms
  • Z
• Synonyms name
  • proteasome subunit β2
• GenBank acession
  • AJ420455
• Locus
  9q33.3
• Discovery year
  1995-11-22
• Entrez gene record
  5695
• Pubmed identfication
  • 8811196
• RefSeq identity
  • NM_002799
• Classification
  • Proteasome
• VEGA ID
  OTTHUMG00000021042

Gene info

• Identity
  HGNC:27396
• Gene
  PLA2G4F
• Long gene name
  phospholipase A2 group IVF
• Synonyms gene name
  • phospholipase A2, group IVF
• Synonyms
  • PLA2G4F/Z
• Locus
  15q15.1
• Discovery year
  2005-11-04
• Entrez gene record
  255189
• Pubmed identfication
  • 14702039
  • 15866882
• RefSeq identity
  • NM_213600
• Classification
  • C2 domain containing phospholipases
  • Phospholipases
• VEGA ID
  OTTHUMG00000172782

Gene info

• Identity
  HGNC:19394
• Gene
  HLA-Z
• Long gene name
  major histocompatibility complex, class I, Z (pseudogene)
• Synonyms
  • HLA-Z1
• Locus
  6p21.32
• Discovery year
  2002-10-23
• Entrez gene record
  267017
• Pubmed identfication
  • 8568858
• RefSeq identity
  • NG_009944
• Classification
  • Histocompatibility complex
• VEGA ID
  OTTHUMG00000031189
• Locus Specific Databases
  • IMGT/HLA Database

Gene info

• Identity
  HGNC:3330
• Gene
  EML1
• Long gene name
  EMAP like 1
• Synonyms gene
  • EMAPL
• Synonyms gene name
  • echinoderm microtubule associated protein like 1
• Synonyms
  • EMAP
  • HuEMAP
  • ELP79
• GenBank acession
  • AK023861
• Locus
  14q32.2
• Discovery year
  1997-07-11
• Entrez gene record
  2009
• Pubmed identfication
  • 9226380
  • 10521658
• RefSeq identity
  • NM_001008707
• Classification
  • WD repeat domain containing
  • EMAP like
• VEGA ID
  OTTHUMG00000171529

Gene info

• Identity
  HGNC:18035
• Gene
  EML2
• Long gene name
  EMAP like 2
• Synonyms gene name
  • echinoderm microtubule associated protein like 2
• Synonyms
  • EMAP2
  • ELP70
  • EMAP-2
• Synonyms name
  • echinoderm MT-associated protein (EMAP)-like protein 70
  • microtubule-associated protein like echinoderm EMAP
• GenBank acession
  • AF103939
• Locus
  19q13.32
• Discovery year
  2002-02-15
• Entrez gene record
  24139
• Pubmed identfication
  • 11694528
  • 10521658
• RefSeq identity
  • NM_012155
• Classification
  • WD repeat domain containing
  • EMAP like
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000182127

Gene info

• Identity
  HGNC:2339
• Gene
  CRABP2
• Long gene name
  cellular retinoic acid binding protein 2
• Synonyms gene name
  • cellular retinoic acid-binding protein 2
• Synonyms
  • CRABP-II
• GenBank acession
  • BC001109
• Locus
  1q23.1
• Discovery year
  1992-11-25
• Entrez gene record
  1382
• Pubmed identfication
  • 1654334
• RefSeq identity
  • NM_001878
• Classification
  • Fatty acid binding protein family
• VEGA ID
  OTTHUMG00000041300

Gene info

• Identity
  HGNC:11245
• Gene
  SPINK2
• Long gene name
  serine peptidase inhibitor Kazal type 2
• Synonyms gene name
  • serine protease inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
• Synonyms
  • HUSI-II
• Synonyms name
  • acrosin-trypsin inhibitor
• GenBank acession
  • BC022514
• Locus
  4q12
• Discovery year
  1993-12-01
• Entrez gene record
  6691
• Pubmed identfication
  • 8428671
• RefSeq identity
  • NM_021114
• Classification
  • Serine peptidase inhibitors, Kazal type
• VEGA ID
  OTTHUMG00000128769

Gene info

• Identity
  HGNC:7063
• Gene
  MGST2
• Long gene name
  microsomal glutathione S-transferase 2
• Synonyms
  • MGST-II
• GenBank acession
  • U77604
• Locus
  4q31.1
• Discovery year
  1997-10-16
• Entrez gene record
  4258
• Pubmed identfication
  • 8703034
• RefSeq identity
  • NM_002413
• Classification
  • Microsomal glutathione S-transferases
• VEGA ID
  OTTHUMG00000133382

Gene info

• Identity
  HGNC:18197
• Gene
  EML5
• Long gene name
  EMAP like 5
• Synonyms gene name
  • echinoderm microtubule associated protein like 5
• Synonyms
  • HuEMAP-2
  • EMAP-2
  • FAP16
• GenBank acession
  • AY357725
• Locus
  14q31.3
• Discovery year
  2002-12-17
• Entrez gene record
  161436
• Classification
  • WD repeat domain containing
  • EMAP like
• VEGA ID
  OTTHUMG00000170811

Product images

Similar products