Ribociclib (LEE011)

• Catalog number
  9481-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
• Description
  Ribociclib is a potent cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.  LEE011 has been shown to reduce proliferation in 12 of 17 human neuroblastoma-derived cell lines by inducing cytostasis (mean IC₅₀ = 306 nM in sensitive lines).
• CAS Number
  1211441-98-3
• Structure Available
  Yes
• Molecular Formula
  C₂₃H₃₀N₈O
• Molecular Weight
  434.54
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~10 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent cyclin-dependent kinase (CDK) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel pack
• Shelf Life
  36 months
• PubChem CID
  44631912
• PubChem CID Link
• SMILES
  CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5
• InChi
  InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28)
• InChi Key
  RHXHGRAEPCAFML-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Ribociclib   LEE011  
• Short name
  Ribociclib (LEE011)
• Alternative name
  Ribociclib (LEE011)

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