C646, p300/CBP Inhibitor
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Catalog number1948-1
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PricePlease ask
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Size1 mg
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Alternative_name(E)-4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)-methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
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DescriptionCell-permeable. A reversible, p300/CBP (CREB-binding protein) histone acetyltransferase (HAT) inhibitor (Ki = 400 nM). Specific inhibition to p300 (86%) compared to N-acetyltransferase, PCAF, GCN5, Rtt109, Sas or MOZ histone acetyltransferases (
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CAS Number328968-36-1
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₄H₁₉N₃O₆
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Molecular Weight445.42
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Cell PermeableYes
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Purity≥98% by NMR
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SolubilitiesDMSO (25 mM)
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HandlingProtect from light and air
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Tag LineA reversible, p300/CBP (CREB-binding protein) histone acetyltransferase (HAT) inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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MDL NumberMFCD01784780
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PubChem CID1285941
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SMILESCC1=C(C=C(C(=C1)C2=CC=C(O2)C=C3C(=NN(C3=O)C4=CC=C(C=C4)C(=O)O)C)[N+](=O)[O-])C
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InChiInChI=1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12-
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InChi KeyHEKJYZZSCQBJGB-UNOMPAQXSA-N
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MSDS AvailableYes
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolPAG1, OPN1LW, CREBBP
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Short nameC646, p300/CBP Inhibitor
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Alternative nameC646, p300/CBP suppressor
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Gene info
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Identity
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Gene
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Long gene namephosphoprotein membrane anchor with glycosphingolipid microdomains 1
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Synonyms gene name
- phosphoprotein associated with glycosphingolipid microdomains 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2005-04-25
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameopsin 1, long wave sensitive
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Synonyms gene
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Synonyms gene name
- color blindness, protan
- red cone photoreceptor pigment
- opsin 1 (cone pigments), long-wave-sensitive
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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RefSeq identity
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Classification
- Opsin receptors
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameCREB binding protein
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Synonyms gene
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Synonyms gene name
- Rubinstein-Taybi syndrome
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Synonyms
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GenBank acession
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Locus
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Discovery year1995-01-10
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Bromodomain containing
- Zinc fingers ZZ-type
- Lysine acetyltransferases
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VEGA ID
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Locus Specific Databases