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Chemical available in other sizes
Please inquire size and price
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Stock availability
In Stock
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Cas number
328968-36-1
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Chemical s molecular weight
445.42
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Chemical s main applications
C646 is an inhibitor for histone acetyltransferase p300 and may be a potential candidate for treating AML1-ETO (AE) positive acute myeloid leukemia (AML). It is shown that C646 inhibited cellular proliferation, reduced colony formation, evoked partial cell cycle arrest in the G1 phase, and induced apoptosis in AE-positive AML cell lines and primary blasts isolated from leukemic mice and AML patients.
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Chemical s category
Amines, Apoptosis, Aromatics, Heterocycles, Inhibitors
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Other name
4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]-benzoic acid; C 646
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Chemical s formula
C24H19N3O6
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Physical properties
Dark Orange Solid
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Melting temperature
>215°C (dec.)
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Boiling temperature
No Data Available
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Chemical s soluble in
DMSO (Slightly), Methanol (Slightly, Heated)
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Stability conditions
No Data Available
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Storage
Amber Vial, -20°C Freezer, Under inert atmosphere
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