Nimbolide

• Catalog number
  1891-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  (4α,5α,6α,7α,15β,17α)-7,15:21,23-Diepoxy-6-hydroxy-4,8-dimethyl-1-oxo-18,24-dinor-11,12-secochola-2,13,20,22-tetraene-4,11-dicarboxylic Αcid γ-lactone Methyl Ester; CCRIS 5723, NSC-309909
• Description
  A terpenoid lactone derived from Azadirachta indica (Neem tree) that displays a variety of biological activities including anti-malarial and anticancer activity. Recently it has also been shown that nimbolide sensitizes colon cancer cells to TRAIL-induced apoptosis through three distinct mechanisms: reactive oxygen species and ERK-mediated up-regulation of DR5 and DR4, downregulation of cell survival proteins, and up-regulation of pro-apoptotic proteins p53 and Bax.
• CAS Number
  25990-37-8
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₇H₃₀O₇
• Molecular Weight
  466.52
• Cell Permeable
  Yes
• Purity
  ≥98% by TLC
• Solubilities
  DMSO (~50 mM) or Ethanol (~ 8 mM)
• Handling
  Protect from air and light
• Tag Line
  An anticancer agent
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD01735386
• PubChem CID
  100017
• PubChem CID Link
• SMILES
  CC1=C2C(CC1C3=COC=C3)OC4C2(C(C5(C6C4OC(=O)C6(C=CC5=O)C)C)CC(=O)OC)C
• InChi
  InChI=1S/C27H30O7/c1-13-15(14-7-9-32-12-14)10-16-20(13)27(4)17(11-19(29) 31-5)26(3)18(28)6-8-25(2)22(26)21(23(27)33-16)34-24(25)30/h6-9,12,15-17, 21-23H,10-11H2,1-5H3
• InChi Key
  JZIQWNPPBKFOPT-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Nimbolide  
• Short name
  Nimbolide
• Alternative name
  Nimbolide

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