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Alternative_name
(4α,5α,6α,7α,15β,17α)-7,15:21,23-Diepoxy-6-hydroxy-4,8-dimethyl-1-oxo-18,24-dinor-11,12-secochola-2,13,20,22-tetraene-4,11-dicarboxylic Αcid γ-lactone Methyl Ester; CCRIS 5723, NSC-309909
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Description
A terpenoid lactone derived from Azadirachta indica (Neem tree) that displays a variety of biological activities including anti-malarial and anticancer activity. Recently it has also been shown that nimbolide sensitizes colon cancer cells to TRAIL-induced apoptosis through three distinct mechanisms: reactive oxygen species and ERK-mediated up-regulation of DR5 and DR4, downregulation of cell survival proteins, and up-regulation of pro-apoptotic proteins p53 and Bax.
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CAS Number
25990-37-8
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₂₇H₃₀O₇
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Molecular Weight
466.52
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Cell Permeable
Yes
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Purity
≥98% by TLC
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Solubilities
DMSO (~50 mM) or Ethanol (~ 8 mM)
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Handling
Protect from air and light
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Tag Line
An anticancer agent
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
36 months
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MDL Number
MFCD01735386
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PubChem CID
100017
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SMILES
CC1=C2C(CC1C3=COC=C3)OC4C2(C(C5(C6C4OC(=O)C6(C=CC5=O)C)C)CC(=O)OC)C
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InChi
InChI=1S/C27H30O7/c1-13-15(14-7-9-32-12-14)10-16-20(13)27(4)17(11-19(29) 31-5)26(3)18(28)6-8-25(2)22(26)21(23(27)33-16)34-24(25)30/h6-9,12,15-17, 21-23H,10-11H2,1-5H3
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InChi Key
JZIQWNPPBKFOPT-UHFFFAOYSA-N
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MSDS Available
Yes