AAL-993

• Catalog number
  2740-10
• Price
  Please ask
• Size
  10 mg

• Alternative_name
  2-((4-Pyridyl)methyl)amino-N-(3-(trifluoromethyl)phenyl)benzamide
• Description
  AAL-993 is a potent, selective and cell-permeable inhibitor of VEGFR-1 (IC₅₀ = 130 nM), VEGFR-2 (IC₅₀ = 23 nM) and VEGFR-3 (IC₅₀ = 18nM). At higher concentrations it inhibits PDGFR (640 nM), c-Kit (236 nM) and CSF-1R (380 nM). Inactive at other kinases such as EGFR, FGFR-1, CDK-1, Tie-2, c-Met, IGF-1R, c-Src and c-Abl. X-ray crystal studies on AAL-993 complexed to the catalytic domain of diphosphorylated VEGFR- 2 indicates that it binds to an inactive conformation of the protein. AAL-993 inhibits VEGF-induced angiogenesis (mouse model).
• CAS Number
  269390-77-4
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₂₀H₁₆F₃N₃O
• Molecular Weight
  371.36
• Cell Permeable
  Yes
• Purity
  ≥98% by TLC
• Solubilities
  DMSO (>25 mg/ml) or EtOH (~15 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent VEGFR inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• PubChem CID
  6398883
• PubChem CID Link
• SMILES
  C1=CC=C(C(=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NCC3=CC=NC=C3
• InChi
  InChI=1S/C20H16F3N3O/c21-20(22,23)15-4-3-5-16(12-15)26-19(27)17-6-1-2-7-18(17)25-13-14-8-10-24-11-9-14/h1-12,25H,13H2,(H,26,27)
• InChi Key
  BLAFVGLBBOPRLP-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  AAL-993  
• Short name
  AAL-993
• Alternative name
  AAL-993

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