Bestrophin 2 Antibody, ALEXA FLUOR 350
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Catalog number
bs-11041R-A350
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Price
Please ask
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Size
100ul
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Long name
Bestrophin 2 Polyclonal Antibody, ALEXA FLUOR 350 Conjugated
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Also known as
Anti-Bestrophin 2 PAb ALEXA FLUOR 350
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Category
Conjugated Primary Antibodies
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Conjugated with
ALEXA FLUOR® 350
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Host Organism
Rabbit (Oryctolagus cuniculus)
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Target Antigen
Bestrophin 2
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Specificity
This is a highly specific antibody against Bestrophin 2.
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Modification
Unmodified
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Modification Site
None
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Clonality
Polyclonal
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Clone
Polyclonal antibody
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Concentration
1ug per 1ul
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Source
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Bestrophin 2
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Tested applications
IF(IHC-P)
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Recommended dilutions
IF(IHC-P)(1:50-200)
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Crossreactivity
Human, Mouse, Rat
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Cross reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the antigen
The Bestrophins are a newly described family of anion channels unrelated in primary sequence to any previously characterized channel proteins. Bestrophins were originally defined as a family of over 20 related sequences of the C. elegans. The first mammalian Bestrophin was identified as the vitelliform macular dystrophy (VMD), 1 also known as Best disease. Three more members of the bestrophin family members were cloned and indentified recently, Bestrophin 2, 3 and 4. RT PCR analyses revealed tissue restricted expression of the three genes with both Bestrophin 1 and Bestrophin 2 are abundantly transcribed in colon. Functionally the bestrophines oligomerise to form tetramers and pentamers in order to act as calcium sensitive chloride channels. It has been shown that Bestrophin interacts with beta catalytic subunit of protein phosphatase 2A (PP2Ac). Such protein protein interaction between Bestrophin and PP2Ac and the structural subunit of PP2A, PR65, was confirmed by reciprocal immunoprecipitation. The interaction between PP2Ac and the Bestrophin takes place near the carboxy terminal end of the protein.
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Purification
Purified by Protein A.
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Storage conditions
Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
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Excitation emission
343nm/442nm
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Synonyms
BEST 2; Best disease Bestrophin; BEST2; Bestrophin2; FLJ20132; Vitellorm macular dystrophy 2 homolog; Vitellorm macular dystrophy 2 like 1; Vitellorm macular dystrophy 2 like protein 1; Vitellorm macular dystrophy; VMD2; VMD2 like gene 1; VMD2L1; BEST2_HUMAN.
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Properties
For facs or microscopy Alexa 1 conjugate. Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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Conjugation
Alexa Fluor, ALEXA FLUOR 350
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French translation
anticorps
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Gene target
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Gene symbol
BEST4, BEST2, BEST3
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Short name
Anti-Bestrophin 2
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Technique
Antibody, antibodies against human proteins, antibodies for
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Isotype
Immunoglobulin G (IgG)
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Label
ALEXA FLUOR 350
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Alternative name
Bestrophin 2 Polyclonal Antibody, ALEXA FLUOR 350
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Alternative technique
antibodies
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Gene info
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Identity
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Gene
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Long gene name
bestrophin 4
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Synonyms gene
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Synonyms gene name
- vitelliform macular dystrophy 2-like 2
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GenBank acession
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Locus
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Discovery year
2003-12-03
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
bestrophin 2
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Synonyms gene
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Synonyms gene name
- vitelliform macular dystrophy 2-like 1
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Synonyms
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GenBank acession
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Locus
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Discovery year
2003-12-03
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
bestrophin 3
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Synonyms gene
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Synonyms gene name
- vitelliform macular dystrophy 2-like 3
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Synonyms
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GenBank acession
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Locus
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Discovery year
2003-12-03
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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