Bestrophin Antibody, ALEXA FLUOR 488

• Catalog number
  bs-11040R-A488
• Price
  Please ask
• Size
  100ul

• Long name
  Bestrophin Polyclonal Antibody, ALEXA FLUOR 488 Conjugated
• Also known as
  Anti-Bestrophin PAb ALEXA FLUOR 488
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 488
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  Bestrophin
• Specificity
  This is a highly specific antibody against Bestrophin.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Bestrophin
• Gene ID Number
  5068
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Best vitelliform macular dystrophy, known as Best disease, is an early-onset autosomal dominant condition in which accumulation of lipofuscin-like material within and beneath the RPE leads to progressive loss of central vision. Best disease is frequently a reflection of mutations in the Bestrophin gene, which encodes a protein containing four putative transmembrane domains and localizes to the basolateral plasma membrane of RPE cells. Human Bestrophin forms oligomeric chloride channels that are sensitive to intracellular calcium. Missense mutations at the Bestrophin locus reduces or abolishes Bestrophin protein mediated membrane current. Bestrophin Bestrophin 2,Bestrophin 3, and Bestrophin 4 are transmembrane proteins that contain a high percentage of aromatic residues, a conserved RFP (Arg-Phe-Pro) motif and they function as anion channels.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  499nm/519nm
• Synonyms
  BEST 1; BEST1; BEST-1; BEST; Best macular dystrophy; BEST1; BEST1_HUMAN; Bestrophin 1; Bestrophin-1; Bestrophin1; BMD; mBest1; TU15B; Vitellorm macular dystrophy 2; Vitellorm macular dystrophy; Vitellorm macular dystrophy protein 2; VMD 2; VMD2.
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-Bestrophin has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor
• French translation
  anticorps

• Gene target
  Bestrophin  
• Gene symbol
  BEST4, BEST2, BEST3
• Short name
  Anti-Bestrophin
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 488
• Alternative name
  Bestrophin Polyclonal Antibody, ALEXA FLUOR 488
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:17106
• Gene
  BEST4
• Long gene name
  bestrophin 4
• Synonyms gene
  • VMD2L2
• Synonyms gene name
  • vitelliform macular dystrophy 2-like 2
• GenBank acession
  • AF440757
• Locus
  1p34.1
• Discovery year
  2003-12-03
• Entrez gene record
  266675
• Pubmed identfication
  • 12032738
  • 16702355
• RefSeq identity
  • NM_153274
• Classification
  • Bestrophins
• VEGA ID
  OTTHUMG00000008488

Gene info

• Identity
  HGNC:17107
• Gene
  BEST2
• Long gene name
  bestrophin 2
• Synonyms gene
  • VMD2L1
• Synonyms gene name
  • vitelliform macular dystrophy 2-like 1
• Synonyms
  • FLJ20132
• GenBank acession
  • AF440756
• Locus
  19p13.13
• Discovery year
  2003-12-03
• Entrez gene record
  54831
• Pubmed identfication
  • 12032738
  • 16912113
• RefSeq identity
  • NM_017682
• Classification
  • Bestrophins
• VEGA ID
  OTTHUMG00000169293

Gene info

• Identity
  HGNC:17105
• Gene
  BEST3
• Long gene name
  bestrophin 3
• Synonyms gene
  • VMD2L3
• Synonyms gene name
  • vitelliform macular dystrophy 2-like 3
• Synonyms
  • MGC40411
  • MGC13168
• GenBank acession
  • AF440758
• Locus
  12q15
• Discovery year
  2003-12-03
• Entrez gene record
  144453
• Pubmed identfication
  • 12032738
• RefSeq identity
  • NM_152439
• Classification
  • Bestrophins
• VEGA ID
  OTTHUMG00000149919

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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