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Alternative_name
Antibiotic G418, G418
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Description
Aminoglycoside antibiotic related to gentamycin that inhibits prokaryotic and eukaryotic protein synthesis. Toxic to bacteria, yeast, protozoans, helminths, higher plant, and mammalian cells. Widely used in the selection of eukaryotic expression vectors carrying the bacterial neor/kanr genes. The product of these genes, aminoglycoside 3′-phosphotransferase, inactivates G418, neomycin, and kanamycin by phosphorylation. Introduction of either of these genes into cells can confer resistance to G418, which enables cells to grow in media containing G418.
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CAS Number
108321-42-2
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Structure Available
Yes
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Salt Form
Yes
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Molecular Formula
C₂₀H₄₀N₄O₁₀. 2 H₂SO₄
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Molecular Weight
692.71
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Cell Permeable
No
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Purity
>720 U/mg (potency)
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Solubilities
H₂O (50 mg/ml)
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Handling
Protect from light and moisture
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Tag Line
An antibiotic and a selection agent
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
24months
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MDL Number
MFCD00058314
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PubChem CID
16760463
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SMILES
CC(C1C(C(C(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O
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InChi
InChI=1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;2*1-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2*(H2,1,2,3,4)
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InChi Key
UHEPSJJJMTWUCP-UHFFFAOYSA-N
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MSDS Available
Yes