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Alternative_name
6-[4-(2-Piperidin-1-yl)-ethoxy)-phenyl)]-3-pyridin-4-yl- pyrazolo[1,5-a]-pyrimidine; Compound C
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Description
Cell-permeable. A potent, selective , reversible and ATP-competitive inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM in the presence of 5 µM ATP and no AMP). Does not affect the activity on several structurally related kinases including JAK3, PKA, PKCθ, SYK and ZAPK. Also inhibits bone morphogenic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). In addition, recently Dorsomorphin has shown to induce protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway.
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CAS Number
866405-64-3
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₂₄H₂₅N₅O
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Molecular Weight
399.49
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Handling
Protect from air and moisture
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Tag Line
An AMP kinase inhibitor
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
12 months
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MDL Number
MFCD08705402
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PubChem CID
11524144
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SMILES
C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3
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InChi
InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2
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InChi Key
XHBVYDAKJHETMP-UHFFFAOYSA-N
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MSDS Available
Yes
