Dorsomorphin Dihydrochloride

Chemical available in other sizes

Please inquire size and price
Stock availability

In Stock
Cas number

1219168-18-9
Chemical s molecular weight

472.41
Chemical s main applications

Dorsomorphin is an AMP-activated kinase (AMPK) inhibitor. Dorsomorphin selectively inhibits the bone morphogenetic protein (BMP) type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1/5/8 phosphorylation, target gene transcription and osteogenic differentiation. Dorsomorphin has shown to to increase cisplatin-induced apoptosis, which was associated with hyper-induction of the tumor suppressor p53.
Chemical s category

Aromatics, Protein Kinase Inhibitors and Activators
Other name

6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine Dihydrochloride; 6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine Hydrochloride (1:2)
Chemical s formula

C24H27Cl2N5O
Physical properties

Yellow Solid
Melting temperature

62-66°C
Boiling temperature

No Data Available
Chemical s soluble in

DMSO, Water
Stability conditions

No Data Available
Storage

Hygroscopic, Refrigerator, under inert atmosphere
Chemical s specifications