BI-D1870

• Catalog number
  1924-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  2-[(3,5-Difluoro-4-hydroxyphenyl)amino]-7,8-dihydro-5,7-dimethyl-8-(3-methylbutyl)-6(5H)-pteridone
• Description
  Cell-permeable. ATP-competitive inhibitor of the four isoforms of ribosomal S6 kinase (p90 RSK) (IC₅₀'s at 100 µM ATP: RSK1 = 31 nM, RSK2 = 24 nM, RSK3 = 18 nM, RSK4 = 15 nM). Does not significantly inhibit 10 other AGC kinases, and over 40 other protein kinases at 100X concentrations.  In addition, BI-D1870 completely prevents PMA-induced TSC2 (a regulator of mTORC1) phosphorylation at Ser¹⁷⁹⁸.
• CAS Number
  501437-28-1
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₉H₂₃F₂N₅O₂
• Molecular Weight
  391.42
• Cell Permeable
  Yes
• Purity
  ≥98% by TLC
• Solubilities
  DMSO (>25 mg/ml)
• Handling
  Protect from light and air
• Tag Line
  An ATP-competitive inhibitor of the four isoforms of ribosomal S6 kinase (p90 RSK)
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD11223662
• PubChem CID
  25023738
• PubChem CID Link
• SMILES
  CC1C(=O)N(C2=CN=C(N=C2N1CCC(C)C)NC3=CC(=C(C(=C3)F)O)F)C
• InChi
  InChI=1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17 (15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24)
• InChi Key
  DTEKTGDVSARYDS-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  BI-D1870  
• Gene symbol
  TMBIM6, SCARB1
• Short name
  BI-D1870
• Alternative name
  BI-D1870

Gene info

• Identity
  HGNC:11723
• Gene
  TMBIM6
• Long gene name
  transmembrane BAX inhibitor motif containing 6
• Synonyms gene
  • TEGT
• Synonyms gene name
  • testis enhanced gene transcript
• Synonyms
  • BI-1
  • BAXI1
• Synonyms name
  • BAX inhibitor 1
• GenBank acession
  • X75861
• Locus
  12q13.12
• Discovery year
  1994-08-30
• Entrez gene record
  7009
• Pubmed identfication
  • 8530040
  • 9660918
• RefSeq identity
  • NM_003217
• Classification
  • Transmembrane BAX inhibitor motif containing
• VEGA ID
  OTTHUMG00000169652

Gene info

• Identity
  HGNC:1664
• Gene
  SCARB1
• Long gene name
  scavenger receptor class B member 1
• Synonyms gene
  • CD36L1
• Synonyms gene name
  • CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1
  • scavenger receptor class B, member 1
• Synonyms
  • SRB1
  • CLA-1
  • CLA1
  • SR-BI
• GenBank acession
  • Z22555
• Locus
  12q24.31
• Discovery year
  1994-09-06
• Entrez gene record
  949
• Pubmed identfication
  • 7689561
• RefSeq identity
  • NM_005505
• Classification
  • Scavenger receptors
• VEGA ID
  OTTHUMG00000168544

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