GSK-3β Inhibitor, TWS119

• Catalog number
  1655-2
• Price
  Please ask
• Size
  2 mg

• Alternative_name
  3-[[6-(3-Aminophenyl)-1H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-phenol
• Description
  A potent inhibitor of GSK-3β (Glycogen synthase kinase-3β) (IC₅₀ = 30 nM). At 400 nM, TWS119 induces neurogenesis in murine embryonic stem cells making it a useful tool to regulate stem cell self-renewal and differentiation.
• CAS Number
  601514-19-6
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₈H₁₄N₄O₂
• Molecular Weight
  318.33
• Cell Permeable
  Yes
• Purity
  ≥95% by HPLC
• Solubilities
  DMSO (20 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A GSK-3β inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD09037535
• PubChem CID
  9549289
• PubChem CID Link
• SMILES
  C1=CC(=CC(=C1)N)C2=CC3=C(N2)N=CN=C3OC4=CC=CC(=C4)O
• InChi
  InChI=1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)
• InChi Key
  VPVLEBIVXZSOMQ-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  GSK-3β   Inhibitor   TWS119  
• Gene symbol
  MIR1302-3, MIR509-3, MIR7-3, PIRC14, PIRC12, MIR9-3, MIR941-3, PIRC15
• Short name
  GSK-3β Inhibitor, TWS119
• Alternative name
  GSK-3β suppressor, TWS119

Gene info

• Identity
  HGNC:35295
• Gene
  MIR1302-3
• Long gene name
  microRNA 1302-3
• Synonyms gene
  • MIRN1302-3
• Synonyms
  • hsa-mir-1302-3
• Locus
  2q14.1
• Discovery year
  2008-11-03
• Entrez gene record
  100302128
• RefSeq identity
  • NR_031632
• Classification
  • MicroRNA MIR1302 family

Gene info

• Identity
  HGNC:33675
• Gene
  MIR509-3
• Long gene name
  microRNA 509-3
• Synonyms gene
  • MIRN509-3
• Synonyms
  • hsa-mir-509-3
• Locus
  Xq27.3
• Discovery year
  2007-10-24
• Entrez gene record
  100126337
• RefSeq identity
  • NR_030629
• Classification
  • MicroRNA MIR506 family

Gene info

• Identity
  HGNC:31640
• Gene
  MIR7-3
• Long gene name
  microRNA 7-3
• Synonyms gene
  • MIRN7-3
• Synonyms
  • hsa-mir-7-3
• Locus
  19p13.3
• Discovery year
  2004-04-23
• Entrez gene record
  407045
• RefSeq identity
  • NR_029607
• Classification
  • MicroRNA MIR7 family

Gene info

• Identity
  HGNC:37518
• Gene
  PIRC14
• Long gene name
  piwi-interacting RNA cluster 14
• Locus
  3
• Discovery year
  2009-11-05
• Entrez gene record
  100313784
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:37516
• Gene
  PIRC12
• Long gene name
  piwi-interacting RNA cluster 12
• Locus
  3
• Discovery year
  2009-11-05
• Entrez gene record
  100313808
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:31646
• Gene
  MIR9-3
• Long gene name
  microRNA 9-3
• Synonyms gene
  • MIRN9-3
• Synonyms
  • hsa-mir-9-3
• Locus
  15q26.1
• Discovery year
  2004-04-23
• Entrez gene record
  407051
• RefSeq identity
  • NR_029692
• Classification
  • MicroRNA MIR9 family

Gene info

• Identity
  HGNC:33686
• Gene
  MIR941-3
• Long gene name
  microRNA 941-3
• Synonyms gene
  • MIRN941-3
• Synonyms
  • hsa-mir-941-3
• Locus
  20q13.33
• Discovery year
  2007-10-24
• Entrez gene record
  100126352
• RefSeq identity
  • NR_030639
• Classification
  • MicroRNAs

Gene info

• Identity
  HGNC:37519
• Gene
  PIRC15
• Long gene name
  piwi-interacting RNA cluster 15
• Locus
  3
• Discovery year
  2009-11-05
• Entrez gene record
  100313848
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Similar products