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Chemical available in other sizes
Please inquire size and price
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Stock availability
In Stock
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Cas number
1337531-89-1
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Chemical s molecular weight
469.43
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Chemical s main applications
GSK PERK Inhibitor is an inhibitor of PERK, an important transmembrane protein of endoplasmic reticulum (ER). GSK PERK Inhibitor can be useful in the treatment of cancer, ocular diseases, and diseases associated with activated unfolded protein response pathways. As a result, GSK PERK Inhibitor has potential use in the treatment of diseases such as Alzheimer's disease, stroke, Type 1 diabetes, Parkinson disease, Huntington's disease, amyotrophic lateral sclerosis, myocardial infarction, cardiovascular disease, atherosclerosis, and arrhythmias, and more specifically cancers of the breast, colon, pancreatic, and lung.
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Chemical s category
Aromatics, Heterocycles, Indole Derivatives, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals,
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Other name
1-[5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone; 3-Fluoro-GSK2606414
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Chemical s formula
C24H19F4N5O
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Physical properties
Off-White to Pale Yellow Solid
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Melting temperature
233-238°C (dec.)
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Boiling temperature
No Data Available
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Chemical s soluble in
DMSO, Methanol (Sparingly)
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Stability conditions
No Data Available
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Storage
Refrigerator
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Description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
