Cholesteryl hemisuccinate

Alternative_name

3β-Hydroxy-5-cholestene 3-hemisuccinate; 5-Cholesten-3β-ol 3-hemisuccinate; CHS
Description

Cholesteryl hemisuccinate is a useful cholesterol-based detergent that increases the stability of G protein-coupled receptors (GPCRs). Together with mutagenesis studies and recent GPCR structures, it has been determined that stabilization is attained through a combination of specific sterol binding to GPCRs and modulation of micelle morphology.
CAS Number

1510-21-0
Structure Available

Yes
Salt Form

No
Molecular Formula

C₃₁H₅₀O₄
Molecular Weight

486.73
Cell Permeable

No
Purity

≥95%
Solubilities

EtOH (warm; with faint turbidity)
Handling

Protect from air and moisture
Tag Line

A detergent that stabilizes GPCRs
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
MDL Number

MFCD00037705
PubChem CID

65082
PubChem CID Link
SMILES

CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC(=O)CCC(=O)O)C)C
InChi

InChI=1S/C31H50O4/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(35-29(34)14-13-28(32)33)15-17-30(22,4)27(24)16-18-31(25,26)5/h9,20-21,23-27H,6-8,10-19H2,1-5H3,(H,32,33)/t21-,23+,24+,25-,26+,27+,30+,31-/m1/s1
InChi Key

WLNARFZDISHUGS-MIXBDBMTSA-N
Data Sheet Link
MSDS Available

Yes