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Alternative_name
Lasmiditan succinate; butanedioic acid,2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)pyridin-2-yl]benzamide; 2,4,6-Trifluoro-N-(6-((1-methylpiperidine-4-yl)carbonyl)pyridin-2-yl)benzamide hemisuccinate; Butanedioic acid, compd. with 2,4,6-trifluoro-N-(6-((1-methyl-4-piperidinyl)carbonyl)-2-pyridinyl)benzamide (1:2); COL-144; LY573144
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Description
Lasmiditan hemisuccinate is a highly selective serotonin 5-HT(1F) receptor agonist. It shows high-affinity for 5-HT(1F) receptor with a Ki value of 2.21 nM in vitro. Oral administration of lasmiditan (3 mg/kg) inhibited markers associated with electrical stimulation of the trigeminal ganglion in rodent models of migraine. It is approved for the acute treatment of migraine with or without aura in adults.
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CAS Number
439239-92-6
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Structure Available
1
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Salt Form
1
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Molecular Formula
C₄₂H₄₂F₆N₆O₈
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Molecular Weight
872.8
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Purity
≥98%
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Solubilities
~9 mg/ml in ethanol, ~14 mg/ml in water, ~100 mg/ml in DMSO
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Handling
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
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Tag Line
A highly selective serotonin 5-HT(1F) receptor agonist
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Storage Condition
-20ºC
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Shipping Condition
RT
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Shelf Life
36 months
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MDL Number
MFCD31728527
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PubChem CID
46927777
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SMILES
CN1CCC(CC1)C(=O)C2=NC(=CC=C2)NC(=O)C3=C(C=C(C=C3F)F)F.CN1CCC(CC1)C(=O)C2=NC(=CC=C2)NC(=O)C3=C(C=C(C=C3F)F)F.C(CC(=O)O)C(=O)O
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InChi
InChI=1S/2C19H18F3N3O2.C4H6O4/c2*1-25-7-5-11(6-8-25)18(26)15-3-2-4-16(23-15)24-19(27)17-13(21)9-12(20)10-14(17)22;5-3(6)1-2-4(7)8/h2*2-4,9-11H,5-8H2,1H3,(H,23,24,27);1-2H2,(H,5,6)(H,7,8)
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InChi Key
MSOIHUHNGPOCTH-UHFFFAOYSA-N
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MSDS Available
1
