Y-27632, dihydrochloride
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Catalog number1596-1
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PricePlease ask
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Size1 mg
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Alternative_nametrans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecar boxamide dihydrochloride
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DescriptionSelective inhibitor of the Rho-associated protein kinase p160ROCK. Ki values are 0.14, 26, 25 and >250 µM for p160ROCK, PKC, cAMP-dependent protein kinase and myosin light-chain kinase, respectively. Prevents apoptosis as well as enhance the survival and cloning efficiency of dissociated human embryonic stem cells (hES) without affecting their pluripotency.
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CAS Number146986-50-7
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₁₄H₂₁N₃O.2HCl
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Molecular Weight320.26
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Cell PermeableYes
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Purity≥99% by HPLC
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SolubilitiesH₂O (100 mM) or PBS (100 mM)
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HandlingProtect from air and moisture
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Tag LineA Rho kinase (ROCK) inhibitor
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Storage Condition-20°C
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Shipping ConditionRT
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Shelf Life24months
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MDL NumberMFCD03490488
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PubChem CID9901617
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SMILESCC(C1CCC(CC1)C(=O)NC2=CC=NC=C2)N.Cl.Cl
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InChiInChI=1S/C14H21N3O.2ClH/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13;;/h6-12H,2-5,15H2,1H3,(H,16,17,18);2*1H/t10-,11?,12?;;/m1../s1
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InChi KeyIDDDVXIUIXWAGJ-DDSAHXNVSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolH3Y1, PSMB6, STSP1, SLC7A7, ANOS2P, H3Y2, GPATCH11
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Short nameY-27632, dihydrochloride
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Alternative nameY-27632, dihydrochloride
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Gene info
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Identity
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Gene
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Long gene nameH3.Y histone 1
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Synonyms
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Locus
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Discovery year2019-08-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- H3 histones
Gene info
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Identity
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Gene
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Long gene nameproteasome 20S subunit beta 6
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Synonyms gene name
- proteasome (prosome, macropain) subunit, beta type, 6
- proteasome subunit beta 6
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1995-05-03
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Proteasome
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namesteroid sulfatase (microsomal) pseudogene 1
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Synonyms gene
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Synonyms gene name
- steroid sulfatase (microsomal) pseudogene
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namesolute carrier family 7 member 7
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Synonyms gene
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Synonyms gene name
- solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-01-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Solute carriers
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameanosmin 2, pseudogene
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Synonyms gene
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Synonyms gene name
- Kallmann syndrome sequence pseudogene
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Synonyms
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GenBank acession
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Locus
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Discovery year1991-08-19
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameH3.Y histone 2
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Synonyms
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Locus
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Discovery year2019-08-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- H3 histones
Gene info
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Identity
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Gene
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Long gene nameG-patch domain containing 11
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Synonyms gene
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Synonyms gene name
- coiled-coil domain containing 75
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2006-02-14
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Entrez gene record
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RefSeq identity
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Classification
- G-patch domain containing
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VEGA ID