JNK-IN-8

• Catalog number
  2729-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  (E)-3-(4-(dimethylamino)but-2-enamido)-N-(3-methyl-4-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)benzamide
• Description
  JNK-IN-8 is a potent and irreversible JNK inhibitor that inhibits the phosphorylation of c-Jun. It inhibits JNK1, JNK2 and JNK4 with IC₅₀ values of of 4.7 nM, 18.7 nM and 1 nM, respectively.
• CAS Number
  1410880-22-6
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₂₉H₂₉N₇O₂
• Molecular Weight
  507.59
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>50 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent and irreversible JNK inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD22124890
• PubChem CID
  57340686
• PubChem CID Link
• SMILES
  CC1=C(C=CC(=C1)NC(=O)C2=CC(=CC=C2)NC(=O)C=CCN(C)C)NC3=NC=CC(=N3)C4=CN=CC=C4
• InChi
  InChI=1S/C29H29N7O2/c1-20-17-24(11-12-25(20)34-29-31-15-13-26(35-29)22-8-5-14-30-19-22)33-28(38)21-7-4-9-23(18-21)32-27(37)10-6-16-36(2)3/h4-15,17-19H,16H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35)/b10-6+
• InChi Key
  GJFCSAPFHAXMSF-UXBLZVDNSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  JNK-IN-8  
• Gene symbol
  SNORD114-8, MAPK8, RNU6-8, SNORD113-8, SNORD116-8, IGKV2OR2-8, MIR1302-8, PIRC35
• Short name
  JNK-IN-8
• Alternative name
  JNK-IN-8

Gene info

• Identity
  HGNC:32996
• Gene
  SNORD114-8
• Long gene name
  small nucleolar RNA, C/D box 114-8
• Synonyms
  • 14q(II-8)
• Locus
  14q32.31
• Discovery year
  2006-09-26
• Entrez gene record
  767584
• Pubmed identfication
  • 12045206
• RefSeq identity
  • NR_003200.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:6881
• Gene
  MAPK8
• Long gene name
  mitogen-activated protein kinase 8
• Synonyms gene
  • PRKM8
• Synonyms
  • JNK
  • JNK1
  • SAPK1
• Synonyms name
  • JUN N-terminal kinase
• GenBank acession
  • L26318
• Locus
  10q11.22
• Discovery year
  1998-04-28
• Entrez gene record
  5599
• Pubmed identfication
  • 8137421
  • 8654373
• Classification
  • Mitogen-activated protein kinases
• VEGA ID
  OTTHUMG00000018172

Gene info

• Identity
  HGNC:34285
• Gene
  RNU6-8
• Long gene name
  RNA, U6 small nuclear 8
• Synonyms
  • U6-8
• Locus
  14q12
• Discovery year
  2008-06-10
• Entrez gene record
  101954278
• Pubmed identfication
  • 12711679
• RefSeq identity
  • NR_104088
• Classification
  • Small nuclear RNAs

Gene info

• Identity
  HGNC:32987
• Gene
  SNORD113-8
• Long gene name
  small nucleolar RNA, C/D box 113-8
• Synonyms
  • 14q(I-8)
• Locus
  14q32.31
• Discovery year
  2006-09-20
• Entrez gene record
  767568
• Pubmed identfication
  • 12045206
• RefSeq identity
  • NR_003236.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:33074
• Gene
  SNORD116-8
• Long gene name
  small nucleolar RNA, C/D box 116-8
• Synonyms
  • HBII-85-8
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033420
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003323
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:5811
• Gene
  IGKV2OR2-8
• Long gene name
  immunoglobulin kappa variable 2/OR2-8 (pseudogene)
• Synonyms gene name
  • immunoglobulin kappa variable 2/OR2-8
  • immunoglobulin kappa variable 2/OR2-8 pseudogene
• Synonyms
  • IGKV2/OR2-8
• GenBank acession
  • X51880
• Locus
  2q11.2
• Discovery year
  2000-04-18
• Entrez gene record
  100996600
• RefSeq identity
  • NG_011662
• Classification
  • Immunoglobulin kappa (IGK) orphons

Gene info

• Identity
  HGNC:35300
• Gene
  MIR1302-8
• Long gene name
  microRNA 1302-8
• Synonyms gene
  • MIRN1302-8
• Synonyms
  • hsa-mir-1302-8
• Locus
  9q22.33
• Discovery year
  2008-11-03
• Entrez gene record
  100302223
• RefSeq identity
  • NR_031637
• Classification
  • MicroRNA MIR1302 family

Gene info

• Identity
  HGNC:37539
• Gene
  PIRC35
• Long gene name
  piwi-interacting RNA cluster 35
• Locus
  8
• Discovery year
  2009-11-05
• Entrez gene record
  100313855
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

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