SIRT2 Inhibitor

• Catalog number
  1857-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  3-(1-azepanylsulfonyl)-N-(3-bromphenyl)benzamide
• Description
  Brain- permeable. A potent and selective sirtuin 2 deacetylase (SIRT2) inhibitor. Reduces neuronal cholesterol by inhibiting SIRT2 activity.
• CAS Number
  420831-40-9
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₉H₂₁BrN₂O₃S
• Molecular Weight
  437.35
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A brain-permeable SIRT2 inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD03140195
• PubChem CID
  1328033
• PubChem CID Link
• SMILES
  C1CCCN(CC1)S(=O)(=O)C2=CC=CC(=C2)C(=O)NC3=CC(=CC=C3)Br
• InChi
  InChI=1S/C19H21BrN2O3S/c20-16-8-6-9-17(14-16)21-19(23)15-7-5-10-18(13-15)26(24,25)22-11-3-1-2-4-12-22/h5-10,13-14H,1-4,11-12H2,(H,21,23)
• InChi Key
  IYAYHZZWYNXHEQ-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  SIRT2   Inhibitor  
• Gene symbol
  SIRT2
• Short name
  SIRT2 Inhibitor
• Alternative name
  SIRT2 suppressor

Gene info

• Identity
  HGNC:10886
• Gene
  SIRT2
• Long gene name
  sirtuin 2
• Synonyms gene
  • SIR2L
• Synonyms gene name
  • sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2
  • sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)
• GenBank acession
  • AF083107
• Locus
  19q13.2
• Discovery year
  1998-10-14
• Entrez gene record
  22933
• Pubmed identfication
  • 10393250
  • 10381378
• Classification
  • Sirtuins
• VEGA ID
  OTTHUMG00000150480

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