Recombinant Rat CD64 / FCGR1A Protein (His tag) 100µg

• Catalog number
  PKSR030404-100µg
• Price
  Please ask
• Size
  100µg

• Synonym
  FcgammaRI;Fcgr1;Fcgr1b
• Activity
  Measured by its binding ability in a functional ELISA. Immobilized Rat CD64-his at 10 μg/ml (100 μl/well) can bind biotinylated human IgG1, The EC50 of biotinylated human IgG1 is 0.04-0.08 μg/ml.
• Sequence
  Met 1-Pro 285
• Fusion tag
  C-His
• Accession
  NP_001094306.1
• ExpressedHost
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  > 95 % as determined by SDS-PAGE
• Endotoxin
  < 1.0 EU per μg of the protein as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  31.6 kDa
• AP Mol Mass
  40-42 KDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  High affinity immunoglobulin gamma Fc receptor I, also known as FCGR1 and CD64, is an integral membrane glycoprotein and a member of the immunoglobulin superfamily. CD64 is a high affinity receptor for the Fc region of IgG gamma and functions in both innate and adaptive immune responses. Receptors that recognize the Fc portion of IgG function in the regulation of immune response and are divided into three classes designated CD64, CD32, and CD16. CD64 is structurally composed of a signal peptide that allows its transport to the surface of a cell, three extracellular immunoglobulin domains of the C2-type that it uses to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail. CD64 is constitutively found on only macrophages and monocytes, but treatment of polymorphonuclear leukocytes with cytokines like IFNγ and G-CSF can induce CD64 expression on these cells. The inactivation of the mouse CD64 resulted in a wide range of defects in antibody Fc-dependent functions. Mouse CD64 is an early participant in Fc-dependent cell activation and in the development of immune responses.
• Technical Data
• Conjugation
  histidine
• About
  Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
• Latin name
  Rattus norvegicus
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CD64   FCGR1A   Protein   His   tag   100µg  
• Gene symbol
  FCGR1A
• Short name
  Recombinant CD64 / FCGR1A Protein (His tag) 100µg
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Host
  Rat
• Label
  His
• Species
  Rat, Rats
• Alternative name
  Rec. Rat CD64 / fragment c fragment on Immunoglobulin G, high affinity Ia, receptor (CD64) Protein (histidine detection labelled) 100µg
• Alternative technique
  rec
• Alternative to gene target
  Fc fragment of IgG, high affinity Ia, receptor (CD64), CD64 and CD64A and FCRI and IGFR1, FCGR1A and IDBG-101961 and ENSG00000150337 and 2209, IgG binding, Plasma membranes

Gene info

• Identity
  HGNC:3613
• Gene
  FCGR1A
• Long gene name
  Fc gamma receptor Ia
• Synonyms gene name
  • Fc fragment of IgG, high affinity Ia, receptor for (CD64)
  • Fc fragment of IgG, high affinity Ia, receptor (CD64)
  • Fc fragment of IgG receptor Ia
• Synonyms
  • CD64
  • CD64A
  • FcgammaRI
  • FcgammaRIa
  • FCG1
  • FCGR1
• Synonyms name
  • Fc gamma RI
• GenBank acession
  • BC032634
• Locus
  1q21.2
• Discovery year
  1992-12-03
• Entrez gene record
  2209
• Pubmed identfication
  • 8697799
  • 9763663
• RefSeq identity
  • NM_000566
• Classification
  • CD molecules
  • Immunoglobulin like domain containing
• VEGA ID
  OTTHUMG00000012089
• Locus Specific Databases
  • FCGR1Abase: Mutation registry for CD64 deficiency
  • LRG_59

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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