Akt Inhibitor (10-NCP)

• Catalog number
  2338-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  10-(4′-(N-diethylamino)butyl)-2-chlorophenoxazine hydrochloride
• Description
  Cell-permeable. A reversible and specific inhibitor of Akt activity in vitro (complete inhibition at < 5 µM). Displays minimal effect on PI 3-K, PDK1, or SGK1. Blocks IGF-I stimulated nuclear translocation of Akt in Rh1 cells and suppressed growth of Rh1, Rh18, and Rh30 cells (IC₅₀ = 2–5 µM). Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein.
• CAS Number
  925681-41-0
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₀H₂₅ClN₂O∙HCl
• Molecular Weight
  381.34
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (60 mg/ml) or H2O (1 mg/ml)
• Handling
  Protect from light and moisture
• Tag Line
  A reversible and specific inhibitor of Akt activity in vitro
• Storage Condition
  -20 ̊C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD09038570
• PubChem CID
  16760284
• PubChem CID Link
• SMILES
  CCN(CC)CCCCN(C(C=C(Cl)C=C1)=C1O2)C3=C2C=CC=C3.[H]Cl
• InChi
  InChI=1S/C20H25ClN2O.ClH/c1-3-22(4-2)13-7-8-14-23-17-9-5-6-10-19(17)24-20-12-11-16(21)15-18(20)23;/h5-6,9-12,15H,3-4,7-8,13-14H2,1-2H3;1H
• InChi Key
  SVKSJUIYYCQZEC-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  Akt   Inhibitor   10-NCP  
• Gene symbol
  SNORD115-10, PIRC49, SNORD116-10, IGKV2OR2-10, IGHV3OR16-10, ERVK-10
• Short name
  Akt Inhibitor (10-NCP)
• Alternative name
  Akt suppressor (10-NCP)

Gene info

• Identity
  HGNC:33029
• Gene
  SNORD115-10
• Long gene name
  small nucleolar RNA, C/D box 115-10
• Synonyms
  • HBII-52-10
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033447
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003302.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:37553
• Gene
  PIRC49
• Long gene name
  piwi-interacting RNA cluster 49
• Locus
  10
• Discovery year
  2009-11-05
• Entrez gene record
  100313929
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:33076
• Gene
  SNORD116-10
• Long gene name
  small nucleolar RNA, C/D box 116-10
• Synonyms
  • HBII-85-10
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033422
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003325
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:5806
• Gene
  IGKV2OR2-10
• Long gene name
  immunoglobulin kappa variable 2/OR2-10 (pseudogene)
• Synonyms gene name
  • immunoglobulin kappa variable 2/OR2-10
  • immunoglobulin kappa variable 2/OR2-10 pseudogene
• Synonyms
  • IGKV2/OR2-10
• GenBank acession
  • X51886
• Locus
  2q11.2
• Discovery year
  2000-04-18
• Entrez gene record
  28855
• RefSeq identity
  • NG_011661
• Classification
  • Immunoglobulin kappa (IGK) orphons

Gene info

• Identity
  HGNC:5634
• Gene
  IGHV3OR16-10
• Long gene name
  immunoglobulin heavy variable 3/OR16-10 (non-functional)
• Synonyms gene name
  • immunoglobulin heavy variable 3/OR16-10
• Synonyms
  • IGHV3/OR16-10
• GenBank acession
  • Z29607
• Locus
  16p11.2
• Discovery year
  2000-04-17
• Entrez gene record
  28306
• Classification
  • Immunoglobulin heavy (IGH) orphons
• VEGA ID
  OTTHUMG00000176446

Gene info

• Identity
  HGNC:39004
• Gene
  ERVK-10
• Long gene name
  endogenous retrovirus group K member 10
• Synonyms gene name
  • endogenous retrovirus group K, member 10
• Synonyms name
  • HERV-K_5q33.3 provirus ancestral Gag polyprotein
  • HERV-K_5q33.3 provirus Np9 protein
  • HERV-K_5q33.3 provirus ancestral Pol protein
  • HERV-K_5q33.3 provirus ancestral Pro protein
• GenBank acession
  • FN806835
  • CF227253
  • CN345079
  • AF164613
• Locus
  5q33.3
• Discovery year
  2011-05-05
• Entrez gene record
  100616101
• Pubmed identfication
  • 18664271
  • 15476554
  • 21542922

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