- Catalog number2338-1
- Product nameAkt Inhibitor (10-NCP)
- Size1 mg
- PriceAsk For Price
- DescriptionCell-permeable. A reversible and specific inhibitor of Akt activity in vitro (complete inhibition at < 5 µM). Displays minimal effect on PI 3-K, PDK1, or SGK1. Blocks IGF-I stimulated nuclear translocation of Akt in Rh1 cells and suppressed growth of Rh1, Rh18, and Rh30 cells (IC₅₀ = 2–5 µM). Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein.
- CAS Number925681-41-0
- Structure AvailableYes
- Salt FormNo
- Molecular FormulaC₂₀H₂₅ClN₂O∙HCl
- Molecular Weight381.34
- Cell PermeableYes
- Purity≥98% by HPLC
- SolubilitiesDMSO (60 mg/ml) or H2O (1 mg/ml)
- HandlingProtect from light and moisture
- Tag LineA reversible and specific inhibitor of Akt activity in vitro
- Storage Condition-20 ̊C
- Shipping Conditiongel pack
- Shelf Life36 months
- MDL NumberMFCD09038570
- PubChem CID16760284
- PubChem CID Link
- SMILESCCN(CC)CCCCN(C(C=C(Cl)C=C1)=C1O2)C3=C2C=CC=C3.[H]Cl
- InChiInChI=1S/C20H25ClN2O.ClH/c1-3-22(4-2)13-7-8-14-23-17-9-5-6-10-19(17)24-20-12-11-16(21)15-18(20)23;/h5-6,9-12,15H,3-4,7-8,13-14H2,1-2H3;1H
- InChi KeySVKSJUIYYCQZEC-UHFFFAOYSA-N
- Data Sheet Link
- MSDS AvailableYes
- Gene targetAkt Inhibitor 10-NCP
- Identity:HGNC:33029
- Gene:SNORD115-10
- Long gene name:small nucleolar RNA, C/D box 115-10
- Synonyms:HBII-52-10
- Discovery year:2007-02-15
- Entrez gene record:100033447
- Pubmed identification:11106375, 11726556
- RefSeq identity:NR_003302.1
- Classification:Small nucleolar RNAs, C/D box
- Identity:HGNC:37553
- Gene:PIRC49
- Long gene name:piwi-interacting RNA cluster 49
- Discovery year:2009-11-05
- Entrez gene record:100313929
- Pubmed identification:17881367
- Classification:Piwi-interacting RNA clusters
- Identity:HGNC:33076
- Gene:SNORD116-10
- Long gene name:small nucleolar RNA, C/D box 116-10
- Synonyms:HBII-85-10
- Discovery year:2007-02-15
- Entrez gene record:100033422
- Pubmed identification:11106375, 11726556
- RefSeq identity:NR_003325
- Classification:Small nucleolar RNAs, C/D box
- Identity:HGNC:5806
- Gene:IGKV2OR2-10
- Long gene name:immunoglobulin kappa variable 2/OR2-10 (pseudogene)
- Synonyms gene name:immunoglobulin kappa variable 2/OR2-10, immunoglobulin kappa variable 2/OR2-10 pseudogene
- Synonyms:IGKV2/OR2-10,
- Discovery year:2000-04-18
- Entrez gene record:28855
- RefSeq identity:NG_011661
- Classification:Immunoglobulin kappa (IGK) orphons
- Identity:HGNC:5634
- Gene:IGHV3OR16-10
- Long gene name:immunoglobulin heavy variable 3/OR16-10 (non-functional)
- Synonyms gene name:immunoglobulin heavy variable 3/OR16-10
- Synonyms:IGHV3/OR16-10
- Discovery year:2000-04-17
- Entrez gene record:28306
- Classification:Immunoglobulin heavy (IGH) orphons
- VEGA ID:OTTHUMG00000176446
- Identity:HGNC:39004
- Gene:ERVK-10
- Long gene name:endogenous retrovirus group K member 10
- Synonyms gene name:endogenous retrovirus group K, member 10
- Discovery year:2011-05-05
- Entrez gene record:100616101
- Pubmed identification:18664271, 15476554, 21542922
- Gene symbolSNORD115-10, PIRC49, SNORD116-10, IGKV2OR2-10, IGHV3OR16-10, ERVK-10
- Short nameAkt Inhibitor (10-NCP)