Lactacystin (Synthetic)

• Catalog number
  1709-200
• Price
  Please ask
• Size
  200 ug

• Alternative_name
  2-(acetylamino)-3-[({3-hydroxy-2-[1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidin-2-yl}carbonyl)sulfanyl]propanoic acid
• Description
  Cell-permeable. A potent and selective inhibitor of the 20 S proteasome. Binds irreversibly to the active site N-terminal threonine residue of the catalytic β-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin-like activities. Induces neurite outgrowth in Neuro 2A neuroblastoma cells and has been reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-kB activation (IC₅₀ = 10 µM).
• CAS Number
  133343-34-7
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₅H₂₄N₂O₇S
• Molecular Weight
  376.42
• Cell Permeable
  Yes
• Purity
  ≥95% by HPLC
• Solubilities
  DMSO (25 mg/ml)
• Handling
  Protect from air and moisture
• Tag Line
  A proteasome inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD01076525
• PubChem CID
  3870
• PubChem CID Link
• SMILES
  CC1C(C(NC1=O)(C(C(C)C)O)C(=O)SCC(C(=O)O)NC(=O)C)O
• InChi
  InChI=1S/C15H24N2O7S/c1-6(2)10(19)15(11(20)7(3)12(21)17-15)14(24)25-5-9(13(22)23)16-8(4)18/h6-7,9-11,19-20H,5H2,1-4H3,(H,16,18)(H,17,21)(H,22,23)
• InChi Key
  DAQAKHDKYAWHCG-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Lactacystin   Synthetic  
• Short name
  Lactacystin (Synthetic)
• Alternative name
  Lactacystin (Synthetic)

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