Lactacystin (Natural)
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Catalog number2434-200
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PricePlease ask
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Size200 ug
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Alternative_name2-(acetylamino)-3-[({3-hydroxy-2-[1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidin-2-yl}carbonyl)sulfanyl]propanoic acid
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DescriptionCell-permeable. A potent and selective inhibitor of the 20 S proteasome. Binds irreversibly to the active site N-terminal threonine residue of the catalytic β-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin-like activities. Induces neurite outgrowth in Neuro 2A neuroblastoma cells and has been reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-kB activation (IC₅₀ = 10 µM).
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CAS Number133343-34-7
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₁₅H₂₄N₂O₇S
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Molecular Weight376.42
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (20 mg/ml) or water (5 mg/ml)
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HandlingProtect from air and moisture
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Tag LineA proteasome inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life24 months
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MDL NumberMFCD01076525
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PubChem CID3870
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SMILESCC1C(C(NC1=O)(C(C(C)C)O)C(=O)SCC(C(=O)O)NC(=O)C)O
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InChiInChI=1S/C15H24N2O7S/c1-6(2)10(19)15(11(20)7(3)12(21)17-15)14(24)25-5-9(13(22)23)16-8(4)18/h6-7,9-11,19-20H,5H2,1-4H3,(H,16,18)(H,17,21)(H,22,23)
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InChi KeyDAQAKHDKYAWHCG-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Short nameLactacystin (Natural)
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Alternative nameLactacystin (Natural)
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