5-Azacytidine, DNA hypomethylation agent
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Catalog numberSIH-345-50MG
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PricePlease ask
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Size50 mg
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Stock availabilitIn StockIn Stock
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CAS number320-67-2
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DescriptionDNA hypomethylation agent
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Molecular weight244,2 g/mol
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Primary research fieldsCell Signaling, Epigenetics, Cancer
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Other name4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one; Ladakamycin; U- 18496; NSC-102816; 5-AzaC
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Product categorySmall Molecules
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Product typeInhibitor
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Chemical formulaC8H12N4O5
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OriginSynthetic
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Purity pourcentage>98% (TLC); NMR (Conforms)
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Soluble inSoluble in 25 mg/ml DMSO or 12 mg/ml Water
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Physical appearanceWhite Solid
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Storage recommendations-20ºC
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Shipping recommendationsShipped Ambient
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Safety informationClassification: Harmful- May be harmful if inhaled, swallowed, or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H302- Harmful if swallowed H350 – May cause cancer Precautionary Statements: P201 – Obtain special instructions before use. P308 + P313 – If exposed or concerned: Get medical advice/attention
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PubChem number9444
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Scientific contextDNA methyltransferase inhibitor. Incorporates into DNA forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of silenced genes. Improves the efficiency of reprogramming of stem cells; induces differentiation of mesenchymal stem cells into cardiomyocytes.
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Bibliography1. Schneider-Stock R., et al. (2005) J Pharmacol Exp Ther. 312(2): 525-536. 2. Mikkelsen T.S., et al., (2008) Nature. 454(7200): 49-55. 3. Qian Q., et al., (2012) Stem Cells Dev. 21(1): 67-75.
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Release date1-Aug-2012
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PubMed numberRefer to PubMed
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Tested applicationsTo be tested
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Tested reactivityTo be tested
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Representative figure legendChemical structure of 5-Azacytidine (SIH-345), a DNA hypomethylation agent. CAS #: 320-67-2. Molecular Formula: C8H12N4O5. Molecular Weight: 244.2 g/mol. Chemical structure of 5-Azacytidine, a DNA hypomethylation agent (SIH-345). CAS # 320-67-2. Molecular Formula: C8H12N4O5.
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Warning informationNon-hazardous
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Country of productionCanada
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Total weight kg0.25
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Net weight g0.05
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Gene target
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Gene symbolPRKDC, HLA-DOA
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Short name5-Azacytidine, DNA hypomethylation agent
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Techniquedna
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Alternative name5-Azacytidine, Desoxyribonucleic acid hypomethylation substance
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Gene info
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Identity
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Gene
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Long gene nameprotein kinase, DNA-activated, catalytic subunit
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Synonyms gene
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Synonyms gene name
- protein kinase, DNA-activated, catalytic polypeptide
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Synonyms
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Synonyms name
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Locus
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Discovery year1993-11-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Armadillo like helical domain containing
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namemajor histocompatibility complex, class II, DO alpha
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Synonyms gene
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- C1-set domain containing
- Histocompatibility complex
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VEGA ID
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Locus Specific Databases