Decitabine, DNA hypomethylation agent

• Catalog number
  SIH-352-10MG
• Price
  Please ask
• Size
  10 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  2353-33-5
• Description
  DNA hypomethylation agent
• Molecular weight
  228,2 g/mol
• Primary research fields
  Cell Signaling, Epigenetics, Cancer
• Other name
  5-Aza-2’-deoxycytidine; NSC-127716, 2'-Deoxy-5-azacytidine; 4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C8H12N4O4
• Origin
  Synthetic
• Purity pourcentage
  >98% (TLC), NMR conforms
• Soluble in
  Soluble in 25 mg/ml DMSO, 11 mg/ml Water or Ethanol
• Physical appearance
  White Solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Harmful – May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H341 – Suspected of causing genetic defects H360 – May damage fertility or the unborn child Precautionary Statements: P280 – Wear protective gloves/protective clothing/ eye protection/ face protection P308+313 – If exposed or concerned: Get Medical Advise/Attention
• PubChem number
  451668
• Scientific context
  Inhibits DNA methyltransferase. Induces demethylation and reactivation of silenced genes. Increases stem cell reprogramming efficiency. Stimulates osteogenic differentiation of human bone marrow stromal cells. Antitumor agent. Cell permeable.
• Bibliography
  1. Bender C.M., et al. (1998) Cancer Res. 58: 95. 2. El-Serafi A.T., et al. (2011) Differentiation 81: 35.
• Release date
  1-Aug-2012
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of Decitabine (SIH-352), a DNA hypomethylation agent. CAS #: 2353-33-5. Molecular Formula: C8H12N4O4. Molecular Weight: 228.2 g/mol. Chemical structure of Decitabine, a DNA hypomethylation agent (SIH-352). CAS # 2353-33-5. Molecular Formula: C8H12N4O4.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.01
• Other related products

• Gene target
  Decitabine   DNA   hypomethylation   agent  
• Gene symbol
  PRKDC, HLA-DOA
• Short name
  Decitabine, DNA hypomethylation agent
• Technique
  dna
• Alternative name
  Decitabine, Desoxyribonucleic acid hypomethylation substance

Gene info

• Identity
  HGNC:9413
• Gene
  PRKDC
• Long gene name
  protein kinase, DNA-activated, catalytic subunit
• Synonyms gene
  • HYRC
  • HYRC1
• Synonyms gene name
  • protein kinase, DNA-activated, catalytic polypeptide
• Synonyms
  • DNPK1
  • p350
  • DNAPK
  • XRCC7
  • DNA-PKcs
  • DNAPKc
  • DNA-PKC
  • p460
• Synonyms name
  • DNA-dependent protein kinase catalytic subunit
• Locus
  8q11.21
• Discovery year
  1993-11-09
• Entrez gene record
  5591
• Pubmed identfication
  • 7638222
• RefSeq identity
  • NM_001081640
• Classification
  • Armadillo like helical domain containing
• VEGA ID
  OTTHUMG00000164239
• Locus Specific Databases
  • LRG_162

Gene info

• Identity
  HGNC:4936
• Gene
  HLA-DOA
• Long gene name
  major histocompatibility complex, class II, DO alpha
• Synonyms gene
  • HLA-DZA
  • HLA-DNA
• Synonyms
  • HLA-D0-alpha
• GenBank acession
  • M31525
• Locus
  6p21.32
• Discovery year
  2001-06-22
• Entrez gene record
  3111
• Pubmed identfication
  • 2370084
• RefSeq identity
  • NM_002119
• Classification
  • C1-set domain containing
  • Histocompatibility complex
• VEGA ID
  OTTHUMG00000031211
• Locus Specific Databases
  • IMGT/HLA Database

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