5-Azacytidine, DNA hypomethylation agent

• Catalog number
  SIH-345-250MG
• Price
  Please ask
• Size
  250 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  320-67-2
• Description
  DNA hypomethylation agent
• Molecular weight
  244,2 g/mol
• Primary research fields
  Cell Signaling, Epigenetics, Cancer
• Other name
  4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one; Ladakamycin; U-18496; NSC-102816; 5-AzaC
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C8H12N4O5
• Origin
  Synthetic
• Purity pourcentage
  >98% (TLC); NMR (Conforms)
• Soluble in
  Soluble in 25 mg/ml DMSO or 12 mg/ml Water
• Physical appearance
  White Solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Harmful- May be harmful if inhaled, swallowed, or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H302- Harmful if swallowed H350 – May cause cancer Precautionary Statements: P201 – Obtain special instructions before use. P308 + P313 – If exposed or concerned: Get medical advice/attention
• PubChem number
  9444
• Scientific context
  DNA methyltransferase inhibitor. Incorporates into DNA forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of silenced genes. Improves the efficiency of reprogramming of stem cells; induces differentiation of mesenchymal stem cells into cardiomyocytes.
• Bibliography
  1. Schneider-Stock R., et al. (2005) J Pharmacol Exp Ther. 312(2): 525-536. 2. Mikkelsen T.S., et al., (2008) Nature. 454(7200): 49-55. 3. Qian Q., et al., (2012) Stem Cells Dev. 21(1): 67-75.
• Release date
  1-Aug-2012
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of 5-Azacytidine (SIH-345), a DNA hypomethylation agent. CAS #: 320-67-2. Molecular Formula: C8H12N4O5. Molecular Weight: 244.2 g/mol. Chemical structure of 5-Azacytidine, a DNA hypomethylation agent (SIH-345). CAS # 320-67-2. Molecular Formula: C8H12N4O5.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.25
• Other related products

• Gene target
  5-Azacytidine   DNA   hypomethylation   agent  
• Gene symbol
  PRKDC, HLA-DOA
• Short name
  5-Azacytidine, DNA hypomethylation agent
• Technique
  dna
• Alternative name
  5-Azacytidine, Desoxyribonucleic acid hypomethylation substance

Gene info

• Identity
  HGNC:9413
• Gene
  PRKDC
• Long gene name
  protein kinase, DNA-activated, catalytic subunit
• Synonyms gene
  • HYRC
  • HYRC1
• Synonyms gene name
  • protein kinase, DNA-activated, catalytic polypeptide
• Synonyms
  • DNPK1
  • p350
  • DNAPK
  • XRCC7
  • DNA-PKcs
  • DNAPKc
  • DNA-PKC
  • p460
• Synonyms name
  • DNA-dependent protein kinase catalytic subunit
• Locus
  8q11.21
• Discovery year
  1993-11-09
• Entrez gene record
  5591
• Pubmed identfication
  • 7638222
• RefSeq identity
  • NM_001081640
• Classification
  • Armadillo like helical domain containing
• VEGA ID
  OTTHUMG00000164239
• Locus Specific Databases
  • LRG_162

Gene info

• Identity
  HGNC:4936
• Gene
  HLA-DOA
• Long gene name
  major histocompatibility complex, class II, DO alpha
• Synonyms gene
  • HLA-DZA
  • HLA-DNA
• Synonyms
  • HLA-D0-alpha
• GenBank acession
  • M31525
• Locus
  6p21.32
• Discovery year
  2001-06-22
• Entrez gene record
  3111
• Pubmed identfication
  • 2370084
• RefSeq identity
  • NM_002119
• Classification
  • C1-set domain containing
  • Histocompatibility complex
• VEGA ID
  OTTHUMG00000031211
• Locus Specific Databases
  • IMGT/HLA Database

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