H-7 dihydrochloride

Alternative_name

(±)-1-(5-Isoquinolinesulphonyl)-2-methylpiperazine dihydrochloride
Description

H-7 is a Protein kinase inhibitor that inhibits the activity of PKA, PKC, PKG and MLCK with IC₅₀ values of 3.0, 6.0, 5.8 and 97.0 µM, respectively.
CAS Number

108930-17-2
Structure Available

Yes
Peptide sequence

N
Salt Form

No
Molecular Formula

C₁₄H₁₇N₃O₂S.2HCl
Molecular Weight

364.29
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>20 mg/ml) or H₂O (>20 mg/ml)
Handling

Protect from air and moisture
Tag Line

A protein kinase inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
MDL Number

MFCD00036961
PubChem CID

73332
PubChem CID Link
SMILES

CC1CNCCN1S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl.Cl
InChi

InChI=1S/C14H17N3O2S.2ClH/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14;;/h2-6,10-11,16H,7-9H2,1H3;2*1H
InChi Key

OARGPFMFRLLKPF-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes

Gene target

H-7 dihydrochloride
Gene symbol

NCAPH, HLA-H, PIRC34, NME7, PIRC33, PIRC32, SNORD114-7, IGHV3OR15-7, IGHV3-69-1, SNORD115-7
Short name

H-7 dihydrochloride
Alternative name

H-7 dihydrochloride

Identity

HGNC:1112
Gene

NCAPH
Long gene name

non-SMC condensin I complex subunit H
Synonyms gene
- BRRN1
Synonyms gene name
- barren (Drosophila) homolog
- barren homolog (Drosophila)
- barren homolog 1 (Drosophila)
- non-SMC condensin I complex, subunit H
Synonyms
- CAP-H
- hCAP-H
GenBank acession
- BC024211
Locus

2q11.2
Discovery year

1998-02-11
Entrez gene record

23397
Pubmed identfication
- 9417923
RefSeq identity
- NM_015341
Classification
- Condensin I subunits
- Kleisins
VEGA ID

OTTHUMG00000130451

Identity

HGNC:20461
Gene

NME7
Long gene name

NME/NM23 family member 7
Synonyms gene name
- non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase)
Synonyms
- FLJ37194
- NM23-H7
- CFAP67
Synonyms name
- cilia and flagella associated protein 67
GenBank acession
- AF153191
Locus

1q24.2
Discovery year

2003-02-24
Entrez gene record

29922
Pubmed identfication
- 19852809
RefSeq identity
- NM_013330
Classification
- NME/NM23 family
- Cilia and flagella associated
VEGA ID

OTTHUMG00000034586

Identity

HGNC:5633
Gene

IGHV3OR15-7
Long gene name

immunoglobulin heavy variable 3/OR15-7 (pseudogene)
Synonyms gene name
- immunoglobulin heavy variable 3/OR15-7
- immunoglobulin heavy variable 3/OR15-7 pseudogene
Synonyms
- IGHV3/OR15-7
GenBank acession
- Z29597
Locus

15q11.2
Discovery year

2000-04-17
Entrez gene record

28318
Classification
- Immunoglobulin heavy (IGH) orphons
VEGA ID

OTTHUMG00000171835

Identity

HGNC:5631
Gene

IGHV3-69-1
Long gene name

immunoglobulin heavy variable 3-69-1 (pseudogene)
Synonyms gene
- IGHV3-H
Synonyms gene name
- immunoglobulin heavy variable 3-H (provisional)
- immunoglobulin heavy variable 3-H pseudogene (provisional)
- immunoglobulin heavy variable 3-H (pseudogene)
Synonyms
- IGHV3-h
GenBank acession
- AJ879484
Locus

14q32.33
Discovery year

2000-04-04
Entrez gene record

28402
Pubmed identfication
- 16133446
Classification
- Immunoglobulin heavy locus at 14q32.33
VEGA ID

OTTHUMG00000191145