Recombinant Human Latexin / LXN / TCI Protein (His tag) 20µg

• Catalog number
  PKSH031755-20µg
• Price
  Please ask
• Size
  20µg

• Synonym
  ECI;TCI
• Activity
  NA
• Sequence
  Glu 2-Glu222
• Fusion tag
  N-His
• Accession
  NP_064554.3
• Expressed Host
  E. coli
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞97 % as determined by SDS-PAGE
• Endotoxin
  Please contact us for more information.
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  26.8 kDa
• AP Mol Mass
  26.8 kDa
• Formulation
  Lyophilized from sterile 20mM HEPES, 0.1M KCl, pH 7.5
• Reconstitution
  Please refer to it for detailed information.
• Background
  Latexin, also known as endogenous carboxypeptidase inhibitor, tissue carboxypeptidase inhibitor, TCI, ECI and LXN, is a cytoplasm protein which belongs to the protease inhibitor I47 (latexin) family. It is highly expressed in heart, prostate, ovary, kidney, pancreas, and colon. Latexin / LXN is the only known endogenous specific inhibitor of zinc-dependent metallocarboxypeptidases (MCPs) present in mammalians so far. Latexin is originally identified as a molecular marker for the regional specification of the neocortex in development in rats. The 222 amino acid latexin in human shows different expression distribution with high levels in heart, prostate, ovary, kidney, pancreas, and colon, but only moderate or low levels in other tissues including brain. Latexin is also expressed at high levels and is inducible in macrophages in concert with other protease inhibitors and potential protease targets, and thus is suggested to play a role in inflammation and innate immunity pathways. Despite of the non-detectable sequence similarity with plant and parasite inhibitors, Latexin is related to a human putative tumor suppressor protein, TIG1. In addition, Latexin is also implicated in Alzheimer's disease.
• Product URL
• PDF URL
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Latexin   LXN   TCI   Protein   His   tag   20µg  
• Gene symbol
  LXN, TCN1
• Short name
  Recombinant Latexin / LXN / TCI Protein (His tag) 20µg
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens Latexin / LXN / TCI Protein (histidine detection labelled) 20µg
• Alternative technique
  rec

Gene info

• Identity
  HGNC:13347
• Gene
  LXN
• Long gene name
  latexin
• GenBank acession
  • AF087851
• Locus
  3q25.32
• Discovery year
  2004-04-30
• Entrez gene record
  56925
• RefSeq identity
  • NM_020169
• VEGA ID
  OTTHUMG00000158807

Gene info

• Identity
  HGNC:11652
• Gene
  TCN1
• Long gene name
  transcobalamin 1
• Synonyms gene name
  • transcobalamin I (vitamin B12 binding protein, R binder family)
  • transcobalamin I
• Synonyms
  • TCI
  • TC1
• Synonyms name
  • haptocorin
  • haptocorrin
• GenBank acession
  • J05068
• Locus
  11q12.1
• Discovery year
  1990-06-11
• Entrez gene record
  6947
• RefSeq identity
  • NM_001062
• VEGA ID
  OTTHUMG00000167400

MeSH Data

• Name
  Latex Fixation Tests
• Concept
  Scope note: Passive agglutination tests in which antigen is adsorbed onto latex particles which then clump in the presence of antibody specific for the adsorbed antigen. (From Stedman, 26th ed)
• Tree numbers
  • E01.370.225.812.735.050.450
  • E05.200.812.735.050.450
  • E05.478.594.760.050.450
• Qualifiers
  ethics, mortality, psychology, trends, veterinary, history, classification, economics, instrumentation, methods, nursing, standards, adverse effects, statistics & numerical data

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