Recombinant Human Latexin / LXN / TCI Protein (Fc tag) 20µg
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Catalog numberPKSH031756-20µg
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PricePlease ask
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Size20µg
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SynonymECI;TCI
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ActivityNA
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SequenceGlu 2-Glu 222
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Fusion tagN-Fc
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AccessionNP_064554.3
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Expressed HostHEK293 Cells
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ShippingIn general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
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Purity>90 % as determined by SDS-PAGE
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Endotoxin<1.0 EU per µg as determined by the LAL method
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Stability and StorageSamples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Mol Mass52 kDa
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AP Mol Mass60-65 kDa
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FormulationLyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH 7.5
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ReconstitutionPlease refer to it for detailed information.
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BackgroundLatexin, also known as endogenous carboxypeptidase inhibitor, tissue carboxypeptidase inhibitor, TCI, ECI and LXN, is a cytoplasm protein which belongs to the protease inhibitor I47 (latexin) family. It is highly expressed in heart, prostate, ovary, kidney, pancreas, and colon. Latexin / LXN is the only known endogenous specific inhibitor of zinc-dependent metallocarboxypeptidases (MCPs) present in mammalians so far. Latexin is originally identified as a molecular marker for the regional specification of the neocortex in development in rats. The 222 amino acid latexin in human shows different expression distribution with high levels in heart, prostate, ovary, kidney, pancreas, and colon, but only moderate or low levels in other tissues including brain. Latexin is also expressed at high levels and is inducible in macrophages in concert with other protease inhibitors and potential protease targets, and thus is suggested to play a role in inflammation and innate immunity pathways. Despite of the non-detectable sequence similarity with plant and parasite inhibitors, Latexin is related to a human putative tumor suppressor protein, TIG1. In addition, Latexin is also implicated in Alzheimer's disease.
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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SourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolLXN, TCN1
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Short nameRecombinant Latexin / LXN / TCI Protein (Fc tag) 20µg
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TechniqueRecombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
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LabelFc Tag
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SpeciesHuman, Humans
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Alternative nameRec. H. sapiens Latexin / LXN / TCI Protein (fragment c detection labelled) 20µg
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Alternative techniquerec
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Gene info
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Identity
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Gene
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Long gene namelatexin
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GenBank acession
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Locus
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Discovery year2004-04-30
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Entrez gene record
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nametranscobalamin 1
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Synonyms gene name
- transcobalamin I (vitamin B12 binding protein, R binder family)
- transcobalamin I
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1990-06-11
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Entrez gene record
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RefSeq identity
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Passive agglutination tests in which antigen is adsorbed onto latex particles which then clump in the presence of antibody specific for the adsorbed antigen. (From Stedman, 26th ed)
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Tree numbers
- E01.370.225.812.735.050.450
- E05.200.812.735.050.450
- E05.478.594.760.050.450
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Qualifiersethics, mortality, psychology, trends, veterinary, history, classification, economics, instrumentation, methods, nursing, standards, adverse effects, statistics & numerical data