RO-3306

• Catalog number
  2039-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  (5Z)-2-((Thiophen-2-yl)methylamino)-5-((quinolin-6-yl)methylene)thiazol-4(5H)-one
• Description
  Cell-permeable. A selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A). Arrests cell cycle at G1, S, and G2/M and induces apoptosis in embryonic stem cells. Actively enhances downstream p53 signaling to promote apoptosis in AML cell lines, and suppresses phosphorylation of p53 at Ser315 and procaspase-8 at Ser387.
• CAS Number
  872573-93-8
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₈H₁₃N₃OS₂
• Molecular Weight
  351.45
• Cell Permeable
  Yes
• Purity
  ≥95% by NMR
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A selective CDK 1 inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• PubChem CID
  44450571
• PubChem CID Link
• SMILES
  C1=CC2=C(C=CC(=C2)C=C3C(=O)N=C(S3)NCC4=CC=CS4)N=C1
• InChi
  InChI=1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)/b16-10+
• InChi Key
  XOLMRFUGOINFDQ-MHWRWJLKSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  RO-3306  
• Gene symbol
  CALR
• Short name
  RO-3306
• Alternative name
  RO-3306

Gene info

• Identity
  HGNC:1455
• Gene
  CALR
• Long gene name
  calreticulin
• Synonyms
  • RO
  • SSA
  • cC1qR
  • CRT
  • FLJ26680
• Synonyms name
  • Sicca syndrome antigen A (autoantigen Ro; calreticulin)
  • autoantigen Ro
• GenBank acession
  • M84739
• Locus
  19p13.13
• Discovery year
  1990-09-10
• Entrez gene record
  811
• Pubmed identfication
  • 2365822
• RefSeq identity
  • NM_004343
• Classification
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000180574
• Locus Specific Databases
  • LRG_828

Product images

Similar products