SIRT7 Antibody

• Catalog number
  6107-50
• Price
  Please ask
• Size
  50 μg

• Antibody Target
  SIRT7
• Target Alternative Name
  SIR2; Sirtuin 7; Silent Information Regulator 7
• Antibody Type
  Polyclonal
• Species Reactivities
  Human
• Immunogen Sequence
  Human SIRT7 aa 35-51 and 361-377
• Accession
  Q9NRC8
• Gene Id
  51547
• Appearance
  Colorless liquid
• Form
  Liquid
• Formulation
  50 µg of antibody in 100 µl PBS containing 0.2% gelatin and 0.05% sodium azide
• Purification
  Protein G purified
• Application
  Western blot
• Positive Control
  Western blot: Human liver homogenate, PBMC lysate
• Application And Usages
  Western blot: 1-3 µg/ml. However, the optimal conditions should be determined individually.
• Description
  The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. SIRT7 is a member of this family of proteins and is present in prokaryotes and eukaryotes. All SIR2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast, and mammalian sirtuins are able to metabolize NAD+ and several act as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but as mentioned above, recent reports of histone-activated SIR2-mediated NAD+ metabolism and NAD+-activated SIR2-mediated histone deacetylation sμggest a possible coupled reciprocal activation mechanism involving interactions of SIR2 with NAD+ and the N-ε-acetyl-lysine groups of acetylated histone.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  SIRT7  
• Gene symbol
  SIRT7
• Short name
  SIRT7 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  SIRT7 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:14935
• Gene
  SIRT7
• Long gene name
  sirtuin 7
• Synonyms gene name
  • sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 7
  • sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae)
• GenBank acession
  • AF233395
• Locus
  17q25.3
• Discovery year
  2001-03-20
• Entrez gene record
  51547
• Pubmed identfication
  • 10873683
  • 16618798
• RefSeq identity
  • NM_016538
• Classification
  • Sirtuins
• VEGA ID
  OTTHUMG00000177957

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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