SIRT7 Antibody

• Catalog number
  bs-5973R
• Price
  Please ask
• Size
  0.1ml

• Long name
  SIRT7 Primary Polyclonal Antibody
• Also known as
  SIRT7 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  SIRT7
• Specificity
  This is a highly specific antibody against SIRT7.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  250-300/400
• Subcellular location
  Cytoplasm, Nucleus
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SIRT7
• Gene ID number
  51547
• Swiss Prot
  Q9NRC8
• Tested Applications
  WB, IHC-P, IHC-F, IF(IHC-P), IF(IHC-F)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IHC-F(1:100-500), IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  SIR2L7; NAD-dependent protein deacetylase sirtuin-7; Regulatory protein SIR2 homolog 7; SIR2-like protein 7; SIRT7
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  SIRT7  
• Gene symbol
  SIRT7
• Short name
  Anti-SIRT7
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  SIRT7 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:14935
• Gene
  SIRT7
• Long gene name
  sirtuin 7
• Synonyms gene name
  • sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 7
  • sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae)
• GenBank acession
  • AF233395
• Locus
  17q25.3
• Discovery year
  2001-03-20
• Entrez gene record
  51547
• Pubmed identfication
  • 10873683
  • 16618798
• RefSeq identity
  • NM_016538
• Classification
  • Sirtuins
• VEGA ID
  OTTHUMG00000177957

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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