Recombinant Mouse Sclerostin/SOST Protein(C-6His)

• Catalog number
  PKSM041137-10µg
• Price
  Please ask
• Size
  10µg

• Synonym
  Sclerostin; Sost
• Activity
  NA
• Sequence
  Gln24-Tyr211
• Fusion tag
  C-6His
• Accession
  Q99P68
• Expressed Host
  Human Cells
• Shipping
  The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
• Purity
  ＞90% as determined by reducing SDS-PAGE.
• Stability and Storage
  Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
• Mol Mass
  21.9 kDa
• AP Mol Mass
  32kDa
• Formulation
  Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
• Background
  Sclerostin (SOST) is a member of the cerberus/DAN family, a group of secreted glycoproteins characterized by a cysteine-knot motif. Cerberus/DAN family members are putative BMP antagonists, and include Dan, Cerberus, Gremlin, PRDC, and Caronte. While the overall sequence identity between members of the family is low, they have conserved spacing of six cysteine residues. Cerberus and Dan have an additional cysteine residue used for dimerization? however, SOST does not and is secreted as a monomer. SOST was originally identified as an important regulator of bone homeostasis. SOST is expressed by osteoclasts in developing bones of mouse embryos, including both intramembranously forming skull bones and endochondrally forming long bones. SOST plays a physiological role as a negative regulator of bone formation by repressing BMP-induced osteogenesis. SOST has been shown to have unique ligand specificity, binding BMP-5, -6, and -7 with high affinity and BMP-2 and -4 with low affinity.
• Technical data
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Sclerostin/SOST   Protein   C-6His  
• Gene symbol
  SOST
• Short name
  Recombinant Mouse Sclerostin/SOST Protein(C-6His)
• Technique
  Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Host
  mouse
• Species
  Mouse, Mouses
• Alternative name
  Rec. Mouse Sclerostin/SOST Protein(C-6His)
• Alternative technique
  rec, murine

Gene info

• Identity
  HGNC:13771
• Gene
  SOST
• Long gene name
  sclerostin
• Synonyms gene name
  • sclerosteosis
• Synonyms
  • VBCH
  • DAND6
• GenBank acession
  • AF326736
• Locus
  17q21.31
• Discovery year
  2002-02-20
• Entrez gene record
  50964
• Pubmed identfication
  • 11179006
  • 11181578
• RefSeq identity
  • NM_025237
• Classification
  • DAN family
• VEGA ID
  OTTHUMG00000180888
• Locus Specific Databases
  • Global Variome shared LOVD
  • LRG_852

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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