Recombinant Human Sclerostin / SOST Protein (His tag)

• Catalog number
  PKSH031512-20µg
• Price
  Please ask
• Size
  20µg

• Synonym
  CDD;DAND6;SOST1;VBCH
• Activity
  NA
• Sequence
  Gln 24-Tyr 213
• Fusion tag
  N-His
• Accession
  NP_079513.1
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞90 % as determined by SDS-PAGE
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  22.5 kDa
• AP Mol Mass
  28 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.2
• Background
  Sclerostin, the protein product of the SOST gene, is a potent inhibitor of bone formation. Sclerostin protein is widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteeoblasts differentiated for 21 days, and was originally identified as an important regulator of bone remodeling, homeostasis, and links bone resorption and bone apposition. Recent studies have revealed that Sclerostin protein inhibits the bone growth probably by binding to the extracellular domain of the Wnt coreceptors LRP5 and LRP6 and disrupting Wnt-induced Frizzled-LRP complex formation.
• Technical data
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Sclerostin   SOST   Protein   His   tag  
• Gene symbol
  SOST
• Short name
  Recombinant Sclerostin / SOST Protein (His tag)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens Sclerostin / SOST Protein (histidine detection labelled)
• Alternative technique
  rec

Gene info

• Identity
  HGNC:13771
• Gene
  SOST
• Long gene name
  sclerostin
• Synonyms gene name
  • sclerosteosis
• Synonyms
  • VBCH
  • DAND6
• GenBank acession
  • AF326736
• Locus
  17q21.31
• Discovery year
  2002-02-20
• Entrez gene record
  50964
• Pubmed identfication
  • 11179006
  • 11181578
• RefSeq identity
  • NM_025237
• Classification
  • DAN family
• VEGA ID
  OTTHUMG00000180888
• Locus Specific Databases
  • Global Variome shared LOVD
  • LRG_852

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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