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MST1 Antibody, Biotin Conjugated

MST1 Antibody, Biotin Conjugated is available 1 time from Bioss primary conjugated antibodies labs

bs-3504R-Biotin | MST1 Antibody, Biotin Conjugated size: 0.1ml | 407.09 USD

Catalog number bs-3504R-Biotin
Price 407.09 USD
Size 0.1ml
1. Gene info
Identity 11408
Gene STK4
Long gene name serine/threonine kinase 4
Synonyms
  • MST1
  • KRS2
  • YSK3
Synonyms name
  • mammalian sterile 20-like 1
  • yeast Ste20-like
  • kinase responsive to stress 2
  • hippo (Drosophila) homolog
Locus 20q13.12
Discovery year 1997-10-09
Entrez gene record 6789
Pubmed identfication
  • 8816758
  • 9545236
  • 11517310
RefSeq identity
  • NM_006282
Havana BLAST/BLAT OTTHUMG00000033059
Locus Specific Databases
  • LRG_535
Product images
    #ntibody#.jpg#.pngMST1 Polyclonal Antibody, Biotin Conjugated
Product files
Long name MST1 Polyclonal Antibody, Biotin Conjugated
Category Conjugated Primary Antibodies
Conjugation Biotin
Host Organism Rabbit (Oryctolagus cuniculus)
Target Antigen MST1
Specificity This is a highly specific antibody against MST1.
Modification Unmodified
Modification site None
Clonality Polyclonal
Clone Polyclonal antibody
Concentration 1ug per 1ul
Immunogen_range 400-450/487
Subcellular location Cytoplasm, Nucleus
Source KLH conjugated synthetic peptide derived from human MST1
Gene ID number 6789
Swiss Prot Q13043
Tested applications WB, IHC-P
Recommended dilutions WB(1:100-1000), IHC-P(1:100-500)
Crossreactivity Human, Mouse, Rat
Crossreactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Antigen background Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.
Purification method This antibody was purified via Protein A.
Storage conditions Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
Excitation Emission N/A
Synonyms KRS2; MST1; YSK3; TIIAC; Serine/threonine-protein kinase 4; Mammalian STE20-like protein kinase 1; MST-1; STE20-like kinase MST1; Serine/threonine-protein kinase Krs-2; STK4
Properties If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Biotin conjugates can be detected by horseradish peroxidase, alkaline phosphatase substrates or anti biotin conjugated antibodies. Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA. To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1.6.
Additional conjugation Biotinylated
French translation anticorps
Gene targetMST1 Conjugated
Short name Anti-MST1
Technique Antibody
Isotype Immunoglobulin G (IgG)
Label Biotin
Alternative name Anti-MST1 PAb Biotin
Alternative technique antibodies
Alternative to gene target macrophage stimulating 1 (hepatocyte growth factor-like), D3F15S2 and DNF15S2 and HGFL and MSP and NF15S2, MST1 and IDBG-35033 and ENSG00000173531 and 4485, serine-type endopeptidase activity, multiple, Mst1 and IDBG-199175 and ENSMUSG00000032591 and 15235, BT.60953 and IDBG-645967 and ENSBTAG00000011585 and 514667
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Anti-MST1 | Technique alternative | 01010936678
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