MST1 Antibody, ALEXA FLUOR 594

• Catalog number
  bs-3504R-A594
• Price
  Please ask
• Size
  100ul

• Long name
  MST1 Polyclonal Antibody, ALEXA FLUOR 594 Conjugated
• Also known as
  Anti-MST1 PAb ALEXA FLUOR 594
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 594
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  MST1
• Specificity
  This is a highly specific antibody against MST1.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  400-450/487
• Subcellular location
  Cytoplasm, Nucleus
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MST1
• Gene ID Number
  6789
• Swiss Prot
  Q13043
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  590nm/617nm
• Synonyms
  KRS2; MST1; YSK3; TIIAC; Serine/threonine-protein kinase 4; Mammalian STE20-like protein kinase 1; MST-1; STE20-like kinase MST1; Serine/threonine-protein kinase Krs-2; STK4
• Properties
  For facs or microscopy Alexa 1 conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• French translation
  anticorps

• Gene target
  MST1  
• Gene symbol
  STK4, MST1
• Short name
  Anti-MST1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  MST1 Polyclonal Antibody, ALEXA FLUOR 594
• Alternative technique
  antibodies
• Alternative to gene target
  macrophage stimulating 1 (hepatocyte growth factor-like), D3F15S2 and DNF15S2 and HGFL and MSP and NF15S2, MST1 and IDBG-35033 and ENSG00000173531 and 4485, serine-type endopeptidase activity, multiple, Mst1 and IDBG-199175 and ENSMUSG00000032591 and 15235, BT.60953 and IDBG-645967 and ENSBTAG00000011585 and 514667

Gene info

• Identity
  HGNC:11408
• Gene
  STK4
• Long gene name
  serine/threonine kinase 4
• Synonyms
  • MST1
  • KRS2
  • YSK3
• Synonyms name
  • mammalian sterile 20-like 1
  • yeast Ste20-like
  • kinase responsive to stress 2
  • hippo (Drosophila) homolog
• Locus
  20q13.12
• Discovery year
  1997-10-09
• Entrez gene record
  6789
• Pubmed identfication
  • 8816758
  • 9545236
  • 11517310
• RefSeq identity
  • NM_006282
• VEGA ID
  OTTHUMG00000033059
• Locus Specific Databases
  • LRG_535

Gene info

• Identity
  HGNC:7380
• Gene
  MST1
• Long gene name
  macrophage stimulating 1
• Synonyms gene
  • D3F15S2
  • HGFL
  • DNF15S2
• Synonyms gene name
  • hepatocyte growth factor-like
• Synonyms
  • MSP
  • NF15S2
• GenBank acession
  • M74178
• Locus
  3p21.31
• Discovery year
  1992-08-24
• Entrez gene record
  4485
• Pubmed identfication
  • 2902784
  • 8393443
• RefSeq identity
  • NM_020998
• VEGA ID
  OTTHUMG00000155918

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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