KMT8; PRDM2; PR Domain Zinc Finger Protein 2; Retinoblastoma Protein-interacting Zinc Finger Protein
49.5 kDa (2-200 aa + NT GST Tag)
Level of endotoxin
For Research Use Only! Not to be used in humans
Retinoblastoma protein-interacting zinc finger protein 1 (RIZ1), also known as PRDM2, is a SAM-dependent histone methyltransferase that specifically methylates histone H3 on lysine 9. RIZ1 contains 8 zinc-finger motifs and 1 PR domain. The RIZ gene encodes two different proteins, RIZ1 and RIZ2. RIZ1 is a tumor suppressor that can arrest the cell cycle and induce apoptosis. RIZ2 however, is a proto-oncoprotein lacking the N-terminal PR domain containing the methyltransferase activity. When RIZ1 is silenced or mutated, the reduced methyltransferase activity can lead to inheritable changes in chromatin methylation and gene expression patterns.
Centrifuge the vial prior to opening.
NCBI gene number
50 mM Tris, pH 7.5, containing 150 mM sodium chloride and 20% glycerol.
RIZ1 (2-200 aa) (GST-tagged), Human recombinant
How to reconstitute
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Recombinants or rec. proteins
RIZ1 (2-200 aa) (GST-tagged) recombinant
RIZ1 (2-200 aa) (GST-tagged), H. sapiens recombinant