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Chemical available in other sizes
Please inquire size and price
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Stock availability
In Stock
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Cas number
86672-58-4
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Chemical s molecular weight
266.29
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Chemical s main applications
URB754 is a potent, noncompetitive inhibitor of MGL, exhibiting an IC50 of 200 nM for the recombinant rat brain enzyme. It inhibits rat brain fatty acyl amide hydrolase (FAAH) less effectively with an IC50 of 32 µM and binds weakly to the rat CB1 receptor with an IC50 of 3.8 µM. It does not inhibit cyclooxygenase-1 (COX-1) or COX-2 at concentrations up to 100 µM. Inhibition of 2-AG hydrolysis is associated with enhanced stress-induced analgesia and may represent a novel drug target in pain and stress management.
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Chemical s category
Aromatics, Heterocycles, Inhibitors
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Other name
6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazine-4-one;
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Chemical s formula
C16H14N2O2
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Physical properties
White to Off-White Solid
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Melting temperature
>202°C (dec.)
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Boiling temperature
No Data Available
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Chemical s soluble in
DMSO (Slightly), Methanol (Slightly, Heated)
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Stability conditions
No Data Available
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Storage
Refrigerator
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