N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide

Chemical available in other sizes

Please inquire size and price
Stock availability

In Stock
Cas number

171887-03-9
Chemical s molecular weight

207.02
Chemical s main applications

N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide is an intermediate of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Chemical s category

Heterocycles, Nucleotides, Bases & Related Reagents
Other name

N-(2-Amino-4,6-dichloropyrimidin-5-yl)formamide;
Chemical s formula

C5H4Cl2N4O
Physical properties

Off-White to Pale Beige Solid
Melting temperature

>251°C (dec.)
Boiling temperature

No Data Available
Chemical s soluble in

DMSO, Methanol
Stability conditions

No Data Available
Storage

Amber Vial, Refrigerator, Under inert atmosphere
Chemical s specifications

Gene target

2-Amino-4 6-dichloro-5-pyrimidinyl formamide
Gene symbol

MIR1302-5, PIRC23, PIRC22, PIRC20, PIRC21, HTR6, IGHV2OR16-5, IGKV3OR2-5, SNORD116-5, TGFB1I1
Short name

N-(2-Amino-4 6-dichloro-5-pyrimidinyl)formamide
Alternative name

N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide

Identity

HGNC:5301
Gene

HTR6
Long gene name

5-hydroxytryptamine receptor 6
Synonyms gene name
- 5-hydroxytryptamine (serotonin) receptor 6
- 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
Synonyms
- 5-HT6
- 5-HT6R
GenBank acession
- L41147
Locus

1p36.13
Discovery year

1997-12-11
Entrez gene record

3362
Pubmed identfication
- 8522988
RefSeq identity
- NM_000871
Classification
- 5-hydroxytryptamine receptors, G protein-coupled
VEGA ID

OTTHUMG00000002713

Identity

HGNC:5832
Gene

IGKV3OR2-5
Long gene name

immunoglobulin kappa variable 3/OR2-5 (pseudogene)
Synonyms gene name
- immunoglobulin kappa variable 3/OR2-5
- immunoglobulin kappa variable 3/OR2-5 pseudogene
Synonyms
- IGKV3/OR2-5
GenBank acession
- X51882
Locus

2q11.2
Discovery year

2000-04-18
Entrez gene record

28854
Classification
- Immunoglobulin kappa (IGK) orphons
VEGA ID

OTTHUMG00000184519