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Chemical available in other sizes
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Stock availability
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Cas number
644961-61-5
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Chemical s molecular weight
364.32
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Chemical s main applications
A selective PAR-2 antagonist. Dose dependently inhibits calcium signaling in Lewis lung carcinoma cells stimulated with a soluble peptide PAR-2 agonist or trypsin, but not with a soluble PAR-1 agonist. Does not inhibit platelet aggregation stimulated by thrombin suggesting that it does not inhibit PAR-3 or PAR-4 signaling. Reduces TNF-a and IL-1β production from rheumatoid arthritis synovial primary cell culture and reduces joint swelling in a carageenan/kaloin-injected mouse model.
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Chemical s category
Amines, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
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Other name
6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone Hydrobromide; 1-(6-Amino-1-oxohexyl)-4-(3-methyl-1-oxobutyl)piperazine Monohydrobromide;
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Chemical s formula
C15H30BrN3O2
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Physical properties
N/A
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Melting temperature
No Data Available
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Boiling temperature
No Data Available
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Chemical s soluble in
No Data Available
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Stability conditions
No Data Available
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Storage
No Data Available
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