AST-1306

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Cas number

897383-62-9
Chemical s molecular weight

448.88
Chemical s main applications

AST-1306 is a selective irreversible inhibitor of the epidermal growth factor receptor (EGFR) 1 and 2. Studies show that AST-1306 inhibited the enzymatic activities of wild-type EGF) and ErbB2 as well as EGFR resistant mutant in both cell-free and cell-based systems. AST-1306 was more effective in inhibiting tumors with ErbB2-overexpressing cells than EGFR-overexpressing tumor.
Chemical s category

Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals,
Other name

N-[4-[[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]amino]quinazolin-6-yl]acrylamide; N-[4-[[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-6-quinazolinyl]-2-propenamide; ALS1306; AST 1306; AST 6;
Chemical s formula

C24H18ClFN4O2
Physical properties

No Data Available
Melting temperature

No Data Available
Boiling temperature

No Data Available
Chemical s soluble in

No Data Available
Stability conditions

No Data Available
Storage

No Data Available
Chemical s specifications

Identity

HGNC:10933
Gene

SLC17A5
Long gene name

solute carrier family 17 member 5
Synonyms gene
- SIASD
Synonyms gene name
- sialic acid storage disease
- solute carrier family 17 (anion/sugar transporter), member 5
- solute carrier family 17 (acidic sugar transporter), member 5
Synonyms
- AST
- SD
- ISSD
- NSD
- SIALIN
- SLD
GenBank acession
- AJ387747
Locus

6q13
Discovery year

2000-01-06
Entrez gene record

26503
Pubmed identfication
- 10581036
- 8198127
Classification
- Solute carriers
VEGA ID

OTTHUMG00000015039