1-(1-Methylethyl)-N-[(6-methyl-2-oxo-4-propyl-1,2-dihydro-3-pyridinyl)methyl]-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1H-indazole-4-carboxamide

• Catalog number
  M304955
• Price
  Please ask
• Size
  1 mg

• Chemical available in other sizes
  Please inquire size and price
• Stock availability
  Available in 2-3 weeks
• Cas number
  1346704-33-3
• Chemical s molecular weight
  541.69
• Chemical s main applications
  1-(1-Methylethyl)-N-[(6-methyl-2-oxo-4-propyl-1,2-dihydro-3-pyridinyl)methyl]-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1H-indazole-4-carboxamide acts as a potent and selective active inhibitor of the histone lysine methyltransferase EZH2 used in cancer treatment.
• Chemical s category
  Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Other name
  N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1H-indazole-4-carboxamide; GSK-343
• Chemical s formula
  C31H39N7O2
• Physical properties
  No Data Available
• Melting temperature
  No Data Available
• Boiling temperature
  No Data Available
• Chemical s soluble in
  No Data Available
• Stability conditions
  No Data Available
• Storage
  No Data Available
• Chemical s specifications
• Description
  A methyl group is an alkyl derived from methane, containing one carbon atom bonded to three hydrogen atoms — CH3. In formulas, the group is often abbreviated Me. Such hydrocarbon groups occur in many organic compounds. It is a very stable group in most molecules. While the methyl group is usually part of a larger molecule, it can be found on its own in any of three forms anion, cation or radical. The anion has eight valence electrons, the radical seven and the cation six. All three forms are highly reactive and rarely observed,

• Gene target
  1-Methylethyl   6-methyl-2-oxo-4-propyl-1   2-dihydro-3-pyridinyl   methyl]   4-methyl-1-piperazinyl   4-pyridinyl]   1H-indazole-4-carboxamide  
• Gene symbol
  IGHV7-4-1, TRC-GCA2-4, TRF-GAA1-4, MIR1302-4, PIRC18, TRG-TCC2-4, TRD-GTC2-4, TRP-TGG3-4
• Short name
  1-(1-Methylethyl)-N-[(6-methyl-2-oxo-4-propyl-1 2-dihydro-3-pyridinyl)methyl]-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1H-indazole-4-carboxamide
• Alternative name
  1-(1-Methylethyl)-N-[(6-methyl-2-oxo-4-propyl-1,2-dihydro-3-pyridinyl)methyl]-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1H-indazole-4-carboxamide

Gene info

• Identity
  HGNC:5665
• Gene
  IGHV7-4-1
• Long gene name
  immunoglobulin heavy variable 7-4-1
• GenBank acession
  • L10057
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  57289
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000191141

Gene info

• Identity
  HGNC:34983
• Gene
  TRC-GCA2-4
• Long gene name
  tRNA-Cys (anticodon GCA) 2-4
• Synonyms gene
  • TRNAC29
  • TRC-GCA2-3
• Synonyms gene name
  • transfer RNA cysteine 29 (anticodon GCA)
  • transfer RNA-Cys (GCA) 2-3
  • transfer RNA-Cys (GCA) 2-4
• Synonyms
  • tRNA-Cys-GCA-2-4
• GenBank acession
  • HG983688
• Locus
  17q12
• Discovery year
  2008-08-29
• Entrez gene record
  100189414
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:33259
• Gene
  TRF-GAA1-4
• Long gene name
  tRNA-Phe (anticodon GAA) 1-4
• Synonyms gene
  • TRNAF2
  • TRF-GAA1-2
• Synonyms gene name
  • transfer RNA phenylalanine 2 (anticodon GAA)
  • transfer RNA-Phe (GAA) 1-2
  • transfer RNA-Phe (GAA) 1-4
• Synonyms
  • tRNA-Phe-GAA-1-4
• GenBank acession
  • HG983961
• Locus
  12q24.31
• Discovery year
  2007-02-01
• Entrez gene record
  100009606
• Pubmed identfication
  • 1191278
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:35296
• Gene
  MIR1302-4
• Long gene name
  microRNA 1302-4
• Synonyms gene
  • MIRN1302-4
• Synonyms
  • hsa-mir-1302-4
• Locus
  2q33.3
• Discovery year
  2008-11-03
• Entrez gene record
  100302130
• RefSeq identity
  • NR_031633
• Classification
  • MicroRNA MIR1302 family

Gene info

• Identity
  HGNC:37522
• Gene
  PIRC18
• Long gene name
  piwi-interacting RNA cluster 18
• Locus
  4
• Discovery year
  2009-11-05
• Entrez gene record
  100313906
• Pubmed identfication
  • 17881367
• Classification
  • Piwi-interacting RNA clusters

Gene info

• Identity
  HGNC:34751
• Gene
  TRG-TCC2-4
• Long gene name
  tRNA-Gly (anticodon TCC) 2-4
• Synonyms gene
  • TRNAG17
• Synonyms gene name
  • transfer RNA glycine 17 (anticodon UCC)
  • transfer RNA-Gly (TCC) 2-4
• Synonyms
  • tRNA-Gly-TCC-2-4
• GenBank acession
  • HG983825
• Locus
  1q23.3
• Discovery year
  2008-08-29
• Entrez gene record
  100189188
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34696
• Gene
  TRD-GTC2-4
• Long gene name
  tRNA-Asp (anticodon GTC) 2-4
• Synonyms gene
  • TRNAD6
• Synonyms gene name
  • transfer RNA aspartic acid 6 (anticodon GUC)
  • transfer RNA-Asp (GTC) 2-4
• Synonyms
  • tRNA-Asp-GTC-2-4
• GenBank acession
  • HG983668
• Locus
  1q23.3
• Discovery year
  2008-08-29
• Entrez gene record
  100189134
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34956
• Gene
  TRP-TGG3-4
• Long gene name
  tRNA-Pro (anticodon TGG) 3-4
• Synonyms gene
  • TRNAP21
  • TRP-TGG3-3
• Synonyms gene name
  • transfer RNA proline 21 (anticodon UGG)
  • transfer RNA-Pro (TGG) 3-3
  • transfer RNA-Pro (TGG) 3-4
• Synonyms
  • tRNA-Pro-TGG-3-4
• GenBank acession
  • HG983999
• Locus
  16p13.3
• Discovery year
  2008-08-29
• Entrez gene record
  100189388
• Classification
  • Cytoplasmic transfer RNAs

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