Zebularine,DNA methylation inhibitor
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Catalog numberSIH-560-2X5MG
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PricePlease ask
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Size2X5 mg
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Research Area sCancer , Tumor suppressors , Stem Cells , Mesenchymal Stem Cells , Cell Signaling , Epigenetics and Nuclear Signaling , DNA/RNA
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CategorySmall Molecules
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Product TypeInhibitor
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CAS No3690-10-6
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MolecularFormulaC9H12N2O5
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Molecular Weight228.2
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Purity>98% (HPLC); NMR (Conforms)
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SolubilityMay be dissolved in DMSO (20 mg/ml); or water (20 mg/ml)
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AppearanceWhite powder
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Storage Temperature-20°C
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Shipping TemperatureBlue Ice or 4ºC
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DescriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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GeneNon-methylated DNA at CpG islands organizes histone methylation through ZF-CxxC proteins in epigenetic biological systems. DNA and histone Methylation is catalyzed by enzymes; such methylation can be involved in hodyonr modification, regulation of gene expression, regulation of protein function, and RNA processing. Methylation of heavy metals can also occur outside biological systems. Chemical methylation of tissue samples is also one method for reducing certain histological staining artifacts. The counterpart of methylation is demethylation.
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Gene target
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Gene symbolPRKDC, HLA-DOA
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Short nameZebularine DNA inhibitor
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Techniquedna
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Alternative nameZebularine,Desoxyribonucleic acid methylation suppressor
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Gene info
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Identity
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Gene
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Long gene nameprotein kinase, DNA-activated, catalytic subunit
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Synonyms gene
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Synonyms gene name
- protein kinase, DNA-activated, catalytic polypeptide
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Synonyms
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Synonyms name
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Locus
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Discovery year1993-11-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Armadillo like helical domain containing
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namemajor histocompatibility complex, class II, DO alpha
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Synonyms gene
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- C1-set domain containing
- Histocompatibility complex
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VEGA ID
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Locus Specific Databases