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Target
NFkB p105 / p50 (pSer907)
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Conjugate
Biotin
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Research Area s
Cell Signaling, Epigenetics and Nuclear Signaling, Nuclear Signaling Pathways, NFkB Pathway, p50, Immunology, Innate Immunity, Macrophage, Cell Signaling, Epigenetics and Nuclear Signaling, Transcription, Transcription Factors, Cell Signaling, Epigenetics and Nuclear Signaling, Transcription, Transcription Factors, Cancer, Apoptosis, Apoptotic Markers
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Alternative Name s
NFkB p105 / p50 Antibody, NF- kappaB p105/p50 Antibody, Nuclear factor NF-kappa-B p105 subunit Antibody, F1 Antibody, Nuclear factor of kappa light polypeptide gene enhancer in B cells 1 Antibody, p84/NF-kappa-B1 p98 Antibody, NF kappabeta Antibody, Nuclear factor of kappa light chain gene enhancer in B cells 1 Antibody, NFKB p50 Antibody, DNA binding factorF1 EBP1 Antibody, EBP 1 Antibody, Transcription factor NFKB1 Antibody, NF kappaB Antibody, NF1 Antibody, NFKB1 Antibody, NFKB p105 Antibody, DKFZp686C01211 Antibody, Nuclear factor kappa-B, subunit 1 Antibody, Nuclear factor NF kappa B p105 subunit Antibody, NF kappa B Antibody, Nuclear factor NF-kappa-B p50 subunit Antibody, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Antibody, NFKB1_HUMAN Antibody, DNA-binding factorF1 Antibody, MGC54151 Antibody, p105 Antibody, Nuclear factor kappa B DNA binding subunit Antibody, DNA binding factorF1 Antibody, nf b Antibody, p50 Antibody, Nuclear factor NF kappa B p50 subunit Antibody, NFKB 1 Antibody, EBP-1 Antibody, EBP1 Antibody, NFkappaB Antibody
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Category
Antibodies
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Product Type
Polyclonal
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Immunogen
Synthetic phospho-peptide from human NFkB p105 / p50 around the phosphorylation site of serine 907 (pSer907).
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Immunogen Species
Human
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Accession Number
NP_001158884.1
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Gene ID
4790
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Swiss Prot
P19838
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Applications
WB, IHC, IP
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Host Species
Rabbit
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Species Reactivity
Human
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Antibody Dilution
WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions); optimal dilutions for assays should be determined by the user.
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Purification
Peptide Affinity Purified
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Storage Buffer
PBS, pH 7.4, 150mM NaCl, 50% glycerol, 0.02% sodium azide
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Specificity
Detects endogenous levels of NFkB p105 / p50 only when phosphorylated at serine 907 (pSer907). Detects a band at ~105 kDa.
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Storage Temperature
-20ºC
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Shipping Temperature
Blue Ice or 4ºC
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Cellular Localization
Nucleus, Cytoplasm, Cytosol, Extracellular Region, Mitochondrion, Nucleoplasm, Secretory Granule Lumen, Specific Granule Lumen, I-Kappab/Nf-Kappab Complex
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Field of Use
For in vitro research use only.
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Gross Weight kg
1.4
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Net Weight g
0.1
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Properties
If you buy Antibodies supplied by StressMarq they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Biotin conjugates can be detected by horseradish peroxidase, alkaline phosphatase substrates or anti biotin conjugated antibodies. Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA. To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1.6.
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Conjugation
Biotinylated
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Gene
NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection (κ light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory
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French translation
anticorps
