Tolcapone, COMT inhibitor
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Catalog number
SIH-540-10MG
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Price
Please ask
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Size
10 mg
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Stock availabilitIn Stock
In Stock
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CAS number
134308-13-7
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Description
COMT inhibitor
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Molecular weight
273,2 g/mol
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Primary research fields
Neuroscience, Neurodegeneration, Parkinson’s Disease
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Other name
(3,4-dihydroxy-5-nitrophenyl)-(4-methylphenyl)methanone, Tolcapone, Tasmar, Ro 40-7592
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C14H11NO5
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Origin
Synthetic
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Purity pourcentage
>98% (TLC); NMR (Conforms)
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Soluble in
Soluble in DMSO (25 mg/ml), or ethanol (25 mg/ml)
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Physical appearance
Yellow powder
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Not WHMIS controlled Hazard statement(s): H303 - May be harmful if swallowed. H400 - Very toxic to aquatic life. Precautionary statement(s) P273 Avoid release to the environment.
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PubChem number
4659569
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Scientific context
Tolcapone is a COMT inhibitor. It inhibits both central and peripheral nervous system catechol-O-methyltransferase (COMT).
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Release date
30/Aug/2016
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Tolcapone (SIH-540), a COMT inhibitor. CAS #: 134308-13-7. Molecular Formula: C14H11NO5. Molecular Weight: 273.2 g/mol. Chemical structure of Tolcapone, a COMT inhibitor (SIH-540). CAS # 134308-13-7. Molecular Formula: C14H11NO5.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.01
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbol
COMT
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Short name
Tolcapone, COMT inhibitor
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Alternative name
Tolcapone, catechol-O-methyltransferase suppressor
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Alternative to gene target
catechol-O-methyltransferase, HEL-S-98n, COMT and IDBG-1506 and ENSG00000093010 and 1312, catechol O-methyltransferase activity, Plasma membranes, Comt and IDBG-141739 and ENSMUSG00000000326 and 12846, COMT and IDBG-638156 and ENSBTAG00000019516 and 618278
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Gene info
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